Elarekibep
Based on 1 Customer Validation
Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma.
For research use only. We do not sell to patients.
- Purity: 98.86%
- CAS No.: 2485020-60-6
- Molecular Weight:16.99 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human
IL-4Ra/CD124
Elarekibep (PRS-060) (0-10 µM) inhibits IL-4- or IL-13-induced STAT-6 phosphorylation with IC50 values of 0.12 nM and 0.10 nM, respectively[1].
PRS-060 (0-10 µM) inhibits hIL-4 or hIL-13 indued proliferation of TF-1 cells with IC50 values of 0.87 nM and 0.92 nM, respectively[1].
PRS-060 (0-10 µM) inhibits hIL-13 induced human epithelial cell mucus transdifferentiation with an IC50 value of 0.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Triple-humanized mouse model[1]
-
Dosage:2, 10, 50 µg/mouse
-
Administration:Intratracheal instillation (i.t)
-
Result:Strongly suppressed acute allergic inflammation indices in triple humanized mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
LCN1 (lipocalin 1) fragment (1-154)
ELISA, FACS, Functional assay
-
Immobilized Elarekibep can bind Human IL-4R Protein (ECD, His Tag). The EC50 for this effect is 13.96 ng/mL. -
Flow cytometric analysis of 1.5×106 Ramos cells labeling Elarekibep (HY-P99935, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.
Chemical Information
-
CAS No. 2485020-60-6
-
Appearance Liquid
-
Molecular Weight 16.99 kDa
-
Color Colorless to light yellow
-
SMILES
[Elarekibep]
-
Synonyms
PRS-060; AZD1402
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (259 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)