1. Inhibitory Antibodies
  2. Elarekibep

Elarekibep  (Synonyms: PRS-060; AZD1402)

Cat. No.: HY-P99935 Purity: 98.86%
COA

Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma.

For research use only. We do not sell to patients.

CAS No. : 2485020-60-6

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Based on 1 publication(s) in Google Scholar

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Description

Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma[1].

Species

Human

In Vitro

Elarekibep (PRS-060) (0-10 µM) inhibits IL-4- or IL-13-induced STAT-6 phosphorylation with IC50 values of 0.12 nM and 0.10 nM, respectively[1].
PRS-060 (0-10 µM) inhibits hIL-4 or hIL-13 indued proliferation of TF-1 cells with IC50 values of 0.87 nM and 0.92 nM, respectively[1].
PRS-060 (0-10 µM) inhibits hIL-13 induced human epithelial cell mucus transdifferentiation with an IC50 value of 0.3 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PRS-060 (i.t; 2, 10, 50 µg) inhibits IL-13-induced eotaxin-1 expression in the lung and ovalbumin-induced acute allergic inflammation in the humanized mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triple-humanized mouse model[1]
Dosage: 2, 10, 50 µg/mouse
Administration: Intratracheal instillation (i.t)
Result: Strongly suppressed acute allergic inflammation indices in triple humanized mice.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Elarekibep]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • LCN1 (lipocalin 1)fragment (1-154)
Biological Activity
  • Immobilized Elarekibep can bind Human IL-4R Protein (ECD, His Tag). The EC50 for this effect is 13.96 ng/mL.
Purity & Documentation
References
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Elarekibep Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Elarekibep
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HY-P99935
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