2. GPCR/G Protein
  3. GCGR
  4. Elsiglutide

Elsiglutide (ZP1846) is a GLP-2 analogue, an orally active and selective GLP-2 receptor agonist, increases cell proliferation and reduces apoptosis in the intestine. Elsiglutide improves Lapatinib (HY-50898)-induced diarrhoea in rat model.

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Elsiglutide Chemical Structure

Elsiglutide Chemical Structure

CAS No. : 914009-84-0

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Elsiglutide Related Antibodies

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Description

Elsiglutide (ZP1846) is a GLP-2 analogue, an orally active and selective GLP-2 receptor agonist, increases cell proliferation and reduces apoptosis in the intestine. Elsiglutide improves Lapatinib (HY-50898)-induced diarrhoea in rat model[1][2].

In Vivo

Elsiglutide (500 mg/kg; p.o.; once daily; 4 times per week for 4 weeks) reduces the most severe diarrhoea seen from Lapatinib (500 mg/kg; p.o.) in rat model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Albino Wistar rats (250-280 g)[1]
Dosage: 500 mg/kg, with or not 500 mg/kg Lapatinib
Administration: Oral gavage; once daily, 4 non-consecutive days per week with vehicle solution being administered on the other 3 days for 4 weeks
Result: Resulted less incidence of diarrhoea compared to lapatinib alone.
Signifcantly less weight gain from day 7 of treatment compared to control.
Clinical Trial
Molecular Weight

4317.98

Formula

C196H323N53O56
CAS No.
Sequence

His-Gly-Glu-Gly-Ser-Phe-Ser-Ser-Glu-Leu-Ser-Thr-Ile-Leu-Asp-Ala-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Ala-Thr-Lys-Ile-Thr-Asp-Lys-Lys-Lys-Lys-Lys-Lys-NH2
Sequence Shortening

HGEGSFSSELSTILDALAARDFIAWLIATKITDKKKKKK-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Elsiglutide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elsiglutide914009-84-0ZP1846ZP 1846ZP-1846GCGRGlucagon Receptorbreast cancerdiarrhoeaelsiglutidelapatinibInhibitorinhibitorinhibit

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HY-P3498
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