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Cat. No.: HY-109088

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Enexasogaol

(Synonyms: trans-6-Shogaol; (E)-[6]-Shogaol)

Enexasogaol (trans-6-Shogaol; (E)-[6]-Shogaol) is the derivative of Shogaol (HY-14616) found in Ginger (Zingiber officinale Rosc). Enexasogaol can be used for the research of cancer .

For research use only. We do not sell to patients.

CAS No.: 23513-13-5
Formula: C₁₇H₂₄O₃
Molecular Weight:276.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

Enexasogaol Chemical Structure

CAS No.: 23513-13-5

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Enexasogaol (trans-6-Shogaol; (E)-[6]-Shogaol) is the derivative of Shogaol (HY-14616) found in Ginger (Zingiber officinale Rosc). Enexasogaol can be used for the research of cancer ^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	5.59 μM Compound: Shogaol	Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated followed by LPS-stimulation by griess assay Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated followed by LPS-stimulation by griess assay	[PMID: 30472026]
HCT-116	IC₅₀	12.87 μM Compound: D7	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST1 assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST1 assay	[PMID: 28065501]
HCT-116	IC₅₀	18.7 μM Compound: [6]-shogaol	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay	[PMID: 22246389]
HEK293	EC₅₀	0.32 μM Compound: 4, [6]-Shogaol	Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry	[PMID: 22257892]
HEK293	EC₅₀	16 μM Compound: 4, [6]-Shogaol	Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry	[PMID: 22257892]
HEK293	IC₅₀	0.29 μM Compound: 4, [6]-Shogaol	Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 mins prior to capsicin-induction by fluo-4-AM-based fluorimetry Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 mins prior to capsicin-induction by fluo-4-AM-based fluorimetry	[PMID: 22257892]
HEK293	IC₅₀	16.7 μM Compound: 4, [6]-Shogaol	Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins prior to AITC-induction by fluo-4-AM-based fluorimetry Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins prior to AITC-induction by fluo-4-AM-based fluorimetry	[PMID: 22257892]
HepG2	IC₅₀	88 μM Compound: 79	Growth inhibition of human HepG2 cells Growth inhibition of human HepG2 cells	[PMID: 31539776]
IMR-32	ED₅₀	24.2 μM Compound: 8	Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay	[PMID: 14980683]
NCI-H1299	IC₅₀	8 μM Compound: [6]-shogaol	Cytotoxicity against human H1299 cells assessed as growth inhibition after 24 hrs by MTT assay Cytotoxicity against human H1299 cells assessed as growth inhibition after 24 hrs by MTT assay	[PMID: 22246389]
PC-12	ED₅₀	16.3 μM Compound: 8	Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay	[PMID: 14980683]
RBL-2H3	IC₅₀	90.4 μM Compound: 4	Cytotoxicity against rat RBL2H3 cells after 12 hrs by MTT assay Cytotoxicity against rat RBL2H3 cells after 12 hrs by MTT assay	[PMID: 19271742]

Chemical Information

CAS No. 23513-13-5
Molecular Weight 276.37
Formula C₁₇H₂₄O₃
SMILES

CCCCC/C=C/C(CCC1=CC(OC)=C(C=C1)O)=O
Synonyms

trans-6-Shogaol; (E)-[6]-Shogaol
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chu-Chin Chen; et al. Chromatographic analyses of isomeric shogaol compounds derived from isolated gingerol compounds of ginger (zingiber officinale roscoe). 360(none), 175–184.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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