2. Others
  3. Drug Derivative
  4. Enexasogaol

Enexasogaol  (Synonyms: trans-6-Shogaol; (E)-[6]-Shogaol)

Cat. No.: HY-109088
Handling Instructions Technical Support

Enexasogaol (trans-6-Shogaol; (E)-[6]-Shogaol) is the derivative of Shogaol (HY-14616) found in Ginger (Zingiber officinale Rosc). Enexasogaol can be used for the research of cancer .

For research use only. We do not sell to patients.

Enexasogaol

Enexasogaol Chemical Structure

CAS No. : 23513-13-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Enexasogaol Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Enexasogaol (trans-6-Shogaol; (E)-[6]-Shogaol) is the derivative of Shogaol (HY-14616) found in Ginger (Zingiber officinale Rosc). Enexasogaol can be used for the research of cancer [1].

Cellular Effect
Cell Line Type Value Description References
BV-2 IC50
5.59 μM
Compound: Shogaol
Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated followed by LPS-stimulation by griess assay
Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated followed by LPS-stimulation by griess assay
[PMID: 30472026]
HCT-116 IC50
12.87 μM
Compound: D7
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST1 assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST1 assay
[PMID: 28065501]
HCT-116 IC50
18.7 μM
Compound: [6]-shogaol
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 22246389]
HEK293 EC50
0.32 μM
Compound: 4, [6]-Shogaol
Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
[PMID: 22257892]
HEK293 EC50
16 μM
Compound: 4, [6]-Shogaol
Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
[PMID: 22257892]
HEK293 IC50
0.29 μM
Compound: 4, [6]-Shogaol
Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 mins prior to capsicin-induction by fluo-4-AM-based fluorimetry
Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 mins prior to capsicin-induction by fluo-4-AM-based fluorimetry
[PMID: 22257892]
HEK293 IC50
16.7 μM
Compound: 4, [6]-Shogaol
Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins prior to AITC-induction by fluo-4-AM-based fluorimetry
Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins prior to AITC-induction by fluo-4-AM-based fluorimetry
[PMID: 22257892]
HepG2 IC50
88 μM
Compound: 79
Growth inhibition of human HepG2 cells
Growth inhibition of human HepG2 cells
[PMID: 31539776]
IMR-32 ED50
24.2 μM
Compound: 8
Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
[PMID: 14980683]
NCI-H1299 IC50
8 μM
Compound: [6]-shogaol
Cytotoxicity against human H1299 cells assessed as growth inhibition after 24 hrs by MTT assay
Cytotoxicity against human H1299 cells assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 22246389]
PC-12 ED50
16.3 μM
Compound: 8
Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
[PMID: 14980683]
RBL-2H3 IC50
90.4 μM
Compound: 4
Cytotoxicity against rat RBL2H3 cells after 12 hrs by MTT assay
Cytotoxicity against rat RBL2H3 cells after 12 hrs by MTT assay
[PMID: 19271742]
Molecular Weight

276.37

Formula

C17H24O3
CAS No.
SMILES

CCCCC/C=C/C(CCC1=CC(OC)=C(C=C1)O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Enexasogaol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enexasogaol23513-13-5trans-6-Shogaol(E)-[6]-ShogaolDrug DerivativeDrug derivativeDerivativeShogaolGingerZingiber officinale RosccancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Enexasogaol
Cat. No.:
HY-109088
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.