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Art. -Nr.: HY-184454

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EP300/CBP ligand 3

CBP/p300 ligand 11 is a ligand of EP300 and CBP, which can be used for PROTAC synthesis, such as serving as the target protein ligand of PROTAC CBP/EP300 Degrader-5 (HY-184453).

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Formel: C₂₇H₂₈N₄O₃
Molecular Weight:456.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

EP300/CBP ligand 3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CBP/p300 ligand 11 is a ligand of EP300 and CBP, which can be used for PROTAC synthesis, such as serving as the target protein ligand of PROTAC CBP/EP300 Degrader-5 (HY-184453)^[1].

IC₅₀ & Target

^[1]

EP300

CBP

Alle Histone Acetyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

CBP/p300 ligand 11 is the target protein ligand of PROTAC CBP/EP300 Degrader-5 (HY-184453). PROTAC CBP/EP300 Degrader-5 is a PROTAC degrader targeting CBP and EP300, which induces G1-phase cell cycle arrest and triggers apoptosis. PROTAC CBP/EP300 Degrader-5 can be used in research related to EP300-dependent malignancies^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 456.54
Formel C₂₇H₂₈N₄O₃
SMILES

O=C([C@@H]1N(C(C2(C3=CC=C(OCC#C)C=C3)CCCC2)=O)CCC1)NC4=CC=CC5=C4C=NN5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tan K, et al. Targeting histone acetyltransferases EP300/CBP by novel proline-based PROTAC degraders. ACS Medicinal Chemistry Letters, 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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