ERK-IN-2
ERK-IN-2 is a ERK2 inhibitor with an IC50 value of 1.8 nM. ERK-IN-2 might lead to off-target toxicity and/or off-target activity at dose >10 μM.
For research use only. We do not sell to patients.
- CAS No.: 2743576-56-7
- Formula: C16H18ClN5O2
- Molecular Weight:347.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERK2 1.8 nM (IC50) |
ERK-IN-2 (ERKi) inhibits RSK phosphorylation with an IC50 of 280 nM[1]. ERK-IN-2 (ERKi, 1 μM) inhibits cell proliferation in cancer cell lines, with IC50 values of 214 nM; 305 nM; 91 nM and 201 nM for A375SM cell, SK-MEL 30 cell; Colo 205 cell and Lovo cell, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2743576-56-7
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Molecular Weight 347.80
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Formula C16H18ClN5O2
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SMILES
OCC1=NC(NC(N[C@H](C)C2=CC=CC=C2)=O)=CC3=C1C=NN3.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERK-IN-2 Related Classifications
HY-133084 Related Classifications
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