Hesperin
Based on 1 Customer Validation
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator.
The product specifications provided below refer solely to the active content of Hesperin.
For research use only. We do not sell to patients.
- Purity : 99.20%
- CAS No.: 4430-35-7
- Formula: C8H15NOS2
- Molecular Weight:205.34
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
The product specifications provided below refer solely to the active content of Hesperin.
IC50 & Target
Nrf2[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.1 | IC50 |
5.7 μM
Compound: 6-MITC
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Antiinflammatory activity in mouse J774.1 cells assessed as inhibition of IFN-gamma and LPS-induced nitric oxide production after 20 to 24 hrs by Griess assay
Antiinflammatory activity in mouse J774.1 cells assessed as inhibition of IFN-gamma and LPS-induced nitric oxide production after 20 to 24 hrs by Griess assay
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[PMID: 19716210] |
| J774.1 | IC50 |
8 μM
Compound: 6-MITC
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Growth inhibition of mouse J774.1 cells assessed as cell viability after 24 hrs by MTT assay
Growth inhibition of mouse J774.1 cells assessed as cell viability after 24 hrs by MTT assay
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[PMID: 19716210] |
In Vitro
Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi (Wasabia japonica Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4430-35-7
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Appearance Liquid
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Molecular Weight 205.34
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Formula C8H15NOS2
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Color Colorless to light yellow
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SMILES
O=S(CCCCCCN=C=S)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Tanaka Y, et al. 6-Methylsulfinylhexyl isothiocyanate prevents high-fat diet-induced fatty liver but fails to attenuate hepatic iron accumulation in mice. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1153-1156. [Content Brief]
[2]. Okamoto T, et al. 6-Methylsulfinylhexyl isothiocyanate modulates endothelial cell function and suppresses leukocyte adhesion. J Nat Med. 2014 Jan;68(1):144-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hesperin Related Classifications
HY-101371 Related Classifications
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