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Cat. No.: HY-185984

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a12k4E-Ca

a12k4E-Ca is a C-terminal glutamate-modified peptidogenic ionizable lipid that can be used for the preparation of lipid nanoparticles (LNPs). a12k4E-Ca preferentially accumulates in the spleen in vivo, acts as a carrier to mediate spleen-selective mRNA delivery, and enables spleen-specific Cre recombinase-mediated gene editing. a12k4E-Ca restores serum biochemical parameters and cytokines/chemokines. a12k4E-Ca can be used in studies related to LNP preparation.

For research use only. We do not sell to patients.

Formula: C₁₂₇H₂₅₁N₉O₉
Molecular Weight:2048.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

a12k4E-Ca Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vivo

a12K4E-Ca LNPs (0.3 mg/kg; intravenous injection; single administration) enable spleen-selective mRNA delivery in healthy female C57BL/6 mice, with organ specificity reaching 91.8%-95.2%^[1].
a12K4E-Ca LNPs (intravenous injection; single dose) preferentially accumulate in the spleen following intravenous administration in healthy female C57BL/6 mice; moreover, they mediate spleen-specific Cre-based gene editing in Ai9 reporter mice, with tdTomato expression levels 3.7-fold higher than those of the control group^[1].
a12K4E-Ca LNPs (4 mg/kg; intravenous injection; single administration) induced transient and recoverable alterations in serum biochemical indicators as well as cytokine and chemokine levels of healthy female C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 2048.41
Formula C₁₂₇H₂₅₁N₉O₉
SMILES

CCCCCCCCCCCCN(CCCC[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCCCCCCCCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin Y, et al. Tissue-specific mRNA delivery and prime editing with peptide-ionizable lipid nanoparticles. Nature materials. 2026 Jan;25(1):133-145. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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