CD72 - CD72 molecule Gene

Also Known as LYB2; CD72b

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 971

About CD72

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,609,982-35,646,857 (from NCBI)

This gene has 10 transcripts (splice variants) and 126 orthologues. Biased expression in lymph node (RPKM 32.2), spleen (RPKM 30.4) and 4 other tissues.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in cell adhesion. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CD72 Products (1)

mRNA Protein Name
NM_001782.3 NP_001773.1 B-cell differentiation antigen CD72

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
1711157 GOA
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
27810925 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
1711157 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
1711157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD72 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (251 - 352)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

B-cell differentiation antigen CD72

  • CD72 antigen

CD72 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD72 P21854 LSMEM2 Homo sapiens Q8N112
Y2H Prey Pooling
32296183
Intra
CD72 P21854 LSMEM2 Homo sapiens Q8N112
Validated Y2H
32296183
Intra
CD72 P21854 LSMEM2 Homo sapiens Q8N112
Y2H Array
32296183
Intra
CD72 P21854 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
CD72 P21854 LRRC25 Homo sapiens Q8N386
Validated Y2H
32296183
Intra
CD72 P21854 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
CD72 P21854 MS4A3 Homo sapiens Q96HJ5
Y2H Prey Pooling
32296183
Intra
CD72 P21854 MS4A3 Homo sapiens Q96HJ5
Validated Y2H
32296183
Intra
CD72 P21854 MS4A3 Homo sapiens Q96HJ5
Y2H Array
32296183
Intra
CD72 P21854 NRG1 Homo sapiens Q02297-10
Y2H Prey Pooling
32296183
Intra
CD72 P21854 NRG1 Homo sapiens Q02297-10
Validated Y2H
32296183
Intra
CD72 P21854 NRG1 Homo sapiens Q02297-10
Y2H Array
32296183
Intra
CD72 P21854 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
CD72 P21854 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
CD72 P21854 SPACA1 Homo sapiens Q9HBV2
Y2H Array
32296183
Intra
CD72 P21854 SPACA1 Homo sapiens Q9HBV2
Validated Y2H
32296183
Intra
CD72 P21854 SPACA1 Homo sapiens Q9HBV2
Y2H Prey Pooling
32296183
Intra
CD72 P21854 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
CD72 P21854 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
CD72 P21854 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra
CD72 P21854 ATP6AP2 Homo sapiens O75787
Y2H Prey Pooling
32296183
Intra
CD72 P21854 ATP6AP2 Homo sapiens O75787
Y2H Array
32296183
Intra
CD72 P21854 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
CD72 P21854 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
CD72 P21854 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
CD72 P21854 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
CD72 P21854 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
CD72 P21854 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
CD72 P21854 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
CD72 P21854 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
CD72 P21854 BIK Homo sapiens Q13323
Validated Y2H
32296183
Intra
CD72 P21854 GRAMD1C Homo sapiens Q8IYS0
Validated Y2H
32296183
Intra
CD72 P21854 GRAMD1C Homo sapiens Q8IYS0
Y2H Array
32296183
Intra
CD72 P21854 GRAMD1C Homo sapiens Q8IYS0
Y2H Prey Pooling
32296183
Intra
CD72 P21854 MS4A7 Homo sapiens Q9GZW8
Y2H Prey Pooling
32296183
Intra
CD72 P21854 MS4A7 Homo sapiens Q9GZW8
Validated Y2H
32296183
Intra
CD72 P21854 MS4A7 Homo sapiens Q9GZW8
Y2H Array
32296183
Intra
CD72 P21854 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
CD72 P21854 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD72 Proteins

Cat. No. Product Name Accession Purity
HY-P72711 CD72 Protein, Human (Trx, His) P21854 (R117-C226) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78903 CD72 Protein, Human (Biotinylated, HEK293, His-Avi) P21854 (R117-D359) ≥ 90%, as determined by reducing SDS-PAGE.

CD72 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85006 CD72 Antibody (YA4698) ELISA, FC Human

Related Diseases

Diseases Alias
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02265 CD72 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19582 Cd72 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26079 Cd72 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991931 Anti-CD72 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CD72 VGNC VGNC:38971
Bos taurus CD72 VGNC VGNC:27045
Macaca mulatta CD72 VGNC VGNC:70778
Rattus norvegicus CD72 RGD RGD:1309757
Mus musculus CD72 MGD MGI:88345
Felis catus CD72 VGNC VGNC:60637
Others CD72 NCBI