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Cat. No.: HY-161877

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GS-7682

GS-7682 is an antiviral compound. GS-7682 has inhibitory activity against pneumoviruses and picornaviruses. GS-7682 can be used in the study of respiratory diseases such as asthma and chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

CAS No.: 2694736-39-3
Formula: C₃₀H₃₇N₆O₁₀P
Molecular Weight:672.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

GS-7682 Chemical Structure

CAS No.: 2694736-39-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	21.1 μM Compound: 1; GS-7682	Cytotoxicity against human A549 cells expressing hACE2 incubated for 28 hrs by Cell Titer Glo assay Cytotoxicity against human A549 cells expressing hACE2 incubated for 28 hrs by Cell Titer Glo assay	[PMID: 39018526]
Epithelial cell	CC₅₀	8.3 μM Compound: 1; GS-7682	Cytotoxicity against Normal human bronchial epithelial cells Cytotoxicity against Normal human bronchial epithelial cells	[PMID: 39018526]
H1-HeLa	CC₅₀	22.2 μM Compound: 1; GS-7682	Cytotoxicity against human H1-HeLa cells incubated for 96 hrs by Cell Titer Glo assay Cytotoxicity against human H1-HeLa cells incubated for 96 hrs by Cell Titer Glo assay	[PMID: 39018526]
HEp-2	CC₅₀	22.7 μM Compound: 1; GS-7682	Cytotoxicity against human Hep-2 cells incubated for 4 to 5 days by Cell Titer Glo assay Cytotoxicity against human Hep-2 cells incubated for 4 to 5 days by Cell Titer Glo assay	[PMID: 39018526]
LLC-MK2	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against rhesus monkey LLC-MK2 cells incubated for 5 days by MTS assay Cytotoxicity against rhesus monkey LLC-MK2 cells incubated for 5 days by MTS assay	[PMID: 39018526]
MDCK	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against MDCK cells by MTS assay Cytotoxicity against MDCK cells by MTS assay	[PMID: 39018526]
MT4	CC₅₀	3.24 μM Compound: 1; GS-7682	Cytotoxicity against human MT4 cells incubated for 5 days by Cell Titer Glo assay Cytotoxicity against human MT4 cells incubated for 5 days by Cell Titer Glo assay	[PMID: 39018526]
RD	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against human RD cells by MTS assay Cytotoxicity against human RD cells by MTS assay	[PMID: 39018526]

Chemical Information

CAS No. 2694736-39-3
Molecular Weight 672.62
Formula C₃₀H₃₇N₆O₁₀P
SMILES

O=[P@](N[C@@H](C)C(OC)=O)(OC1=CC=CC=C1)OC[C@]2(C#N)[C@@H](OC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@H](C3=CC=C4N3N=CN=C4N)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Siegel DS, et al. Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys. J Med Chem. 2024 Jul 17. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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