MK771
MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome.
For research use only. We do not sell to patients.
- CAS No.: 66537-55-1
- Formula: C16H22N6O4S
- Molecular Weight:394.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MK771 (10 ng-10 µg/mouse; i.c.v.) produces a hyperthermic response in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:20-30 g, male MF1 mice[1]
-
Dosage:5 mg/kg
-
Administration:I.p.
-
Result:Induced blinking and forepaw licking in both acutely isolated and paired mice.
-
Animal Model:20-30 g, male MF1 mice[1]
-
Dosage:0.25-60 mg/kg
-
Administration:I.p.
-
Result:Induced blinking was bell-shaped with an ED50 value of 1.72 mg/kg.
-
Animal Model:25-30 g, Male Swiss-Webster mice[2]
-
Dosage:10 ng-10 µg/mouse
-
Administration:I.c.v.
-
Result:Produced a hyperthermic response for 4 h followed by a return to normal temperature.
Chemical Information
-
CAS No. 66537-55-1
-
Molecular Weight 394.45
-
Formula C16H22N6O4S
-
SMILES
O=C(N[C@H](C(N1CSC[C@@H]1C(N)=O)=O)CC2=CNC=N2)[C@@H](N3)CCCC3=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. McCreary AC, et al. The thyrotrophin-releasing hormone analogue MK771 induces tic-like behaviours: the effects of dopamine D1 and D2 receptor antagonists. Eur J Pharmacol. 1999 Mar 12;369(1):1-9. [Content Brief]
[2]. Bhargava HN, et al. Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome. Psychopharmacology (Berl). 1985;87(2):141-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MK771 Related Classifications
HY-119174 Related Classifications
Powered by Bioz