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Referencia número: HY-183076

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AW00718

AW00718 is a Brachyspira pilosicoli glutamate racemase (Bp-MurI) inhibitor. AW00718 binds to Bp-MurI active site residues, forming stable hydrogen bonds and interactions with conserved amino acids in the enzyme’s binding cavity. AW00718 exerts antibacterial and bactericidal activity against Brachyspira pilosicoli in vitro. AW00718 can be used for the research of intestinal spirochaetosis.

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No. CAS: 215778-00-0
Fòrmula: C₁₇H₁₃BrN₄S
Peso molecular:385.28

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

AW00718 Chemical Structure

No. CAS: 215778-00-0

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Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

AW00718 forms a stable complex with homology-modelled Brachyspira pilosicoli glutamate racemase (Bp-MurI)^[1].
AW00718 (5 days) inhibits the growth of Brachyspira pilosicoli strain BP2904 in vitro with a MIC₅₀ of 0.25 mM and a MIC₁₀₀ of 0.5 mM^[1].
AW00718 (1 mM; 24 h) causes ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 24 hours of treatment and 6 hours of Resazurin (HY-118540) exposure, with no cytotoxicity detected after 24 hours of Resazurin exposure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human Chang conjunctival epithelial cells
Concentration:

1 mM
Incubation Time:

24 h following6 h (Resazurin exposure); 24 h (Resazurin exposure single)
Result:

Induced ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 6 hours of Resazurin exposure.
Caused 0% cytotoxicity after 24 hours of resazurin single exposure.

Chemical Information

No. CAS 215778-00-0
Peso molecular 385.28
Fòrmula C₁₇H₁₃BrN₄S
SMILES

BrC1=CC=C(NC2=C3N=NC(SCC4=CC=C(C)C=C4)=N2)C3=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kant R, et al. Identification of small molecule inhibitors for the Brachyspira pilosicoli glutamate racemase (Bp-MurI) enzyme using a computational and experimental approach. Sci Rep. 2026 Apr 2. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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