country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

DOK6 - docking protein 6 Gene

Also Known as DOK5L; HsT3226

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 220164

About DOK6

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:69,400,888-69,849,087 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 7 paralogues. Biased expression in brain (RPKM 6.3), kidney (RPKM 1.5) and 10 other tissues.

Summary

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

DOK6 Products (1)

mRNA	Protein	Name
NM_152721.6	NP_689934.2	docking protein 6

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOK6 Protein Structure

IRS

0
100
200
300
331 a.a.

Protein Preferred Names	Protein Names
docking protein 6	downstream of tyrosine kinase 6

DOK6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	DOK6	Q6PKX4	TBX15	Homo sapiens	Q96SF7	Validated Y2H	32296183
Intra	DOK6	Q6PKX4	TBX15	Homo sapiens	Q96SF7	Y2H Array	32296183
Intra	DOK6	Q6PKX4	TBX15	Homo sapiens	Q96SF7	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	32296183
Intra	DOK6	Q6PKX4	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	DOK6	Q6PKX4	USP54	Homo sapiens	Q70EL1-9	Validated Y2H	32296183
Intra	DOK6	Q6PKX4	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	DOK6	Q6PKX4	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Array	32296183
Intra	DOK6	Q6PKX4	ABHD11	Homo sapiens	Q8NFV4-4	Validated Y2H	32296183
Intra	DOK6	Q6PKX4	FAM86C1P	Homo sapiens	Q9NVL1-2	Validated Y2H	32296183
Intra	DOK6	Q6PKX4	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Array	32296183
Intra	DOK6	Q6PKX4	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	SLC30A6	Homo sapiens	Q6NXT4-4	Y2H Array	32296183
Intra	DOK6	Q6PKX4	SLC30A6	Homo sapiens	Q6NXT4-4	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	CRYBB3	Homo sapiens	P26998	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	CRYBB3	Homo sapiens	P26998	Y2H Array	32296183
Intra	DOK6	Q6PKX4	NTRK3	Homo sapiens	Q16288	Y2H	20565848
Intra	DOK6	Q6PKX4	NTRK3	Homo sapiens	Q16288	Anti Tag CoIP	20565848
Intra	DOK6	Q6PKX4	NTRK3	Homo sapiens	Q16288	Pull Down	20565848
Intra	DOK6	Q6PKX4	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	DOK6	Q6PKX4	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	DOK6	Q6PKX4	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	DOK6	Q6PKX4	METTL27	Homo sapiens	Q8N6F8	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	METTL27	Homo sapiens	Q8N6F8	Validated Y2H	32296183
Intra	DOK6	Q6PKX4	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32296183
Intra	DOK6	Q6PKX4	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	DOK6	Q6PKX4	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	DOK6	Q6PKX4	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	DOK6	Q6PKX4	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	DOK6	Q6PKX4	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Malignant Iris Melanoma	Malignant Melanoma Of Iris Melanoma Of The Iris
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS03938	DOK6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DOK6	VGNC	VGNC:61585
Mus musculus	DOK6	MGD	MGI:3639495
Bos taurus	DOK6	VGNC	VGNC:28169
Macaca mulatta	DOK6	VGNC	VGNC:71915
Rattus norvegicus	DOK6	RGD	RGD:1564376
Canis familiaris	DOK6	VGNC	VGNC:40060
Others	DOK6	NCBI