PTPRR - protein tyrosine phosphatase receptor type R Gene

Also Known as PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5801

About PTPRR

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,638,073-70,920,738 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 35 paralogues. Biased expression in brain (RPKM 5.7), colon (RPKM 3.2) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine Phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

PTPRR Products (4)

mRNA	Protein	Name
NM_001207015.2	NP_001193944.1	receptor-type tyrosine-protein phosphatase R isoform 3
NM_001207016.1	NP_001193945.1	receptor-type tyrosine-protein phosphatase R isoform 4
NM_002849.4	NP_002840.2	receptor-type tyrosine-protein phosphatase R isoform 1 precursor
NM_130846.3	NP_570897.2	receptor-type tyrosine-protein phosphatase R isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10601328	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in ERBB2 signaling pathway	IMP IMP: Inferred from mutant phenotype	21724833	GOA
involved in in utero embryonic development	IEP IEP: Inferred from expression pattern	10601328	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21724833	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	21724833	GOA
NOT involved in regulation of homophilic cell adhesion	IMP IMP: Inferred from mutant phenotype	21724833	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRR Protein Structure

Y_phosphatase

0
200
400
600
657 a.a.

Protein Preferred Names	Protein Names
receptor-type tyrosine-protein phosphatase R	Ch-1 PTPase

PTPRR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	PTPRR	Q15256	INSR	Homo sapiens	P06213	Ub Reconstruction	28065597
Intra	PTPRR	Q15256	ERBB2	Homo sapiens	P04626	Ub Reconstruction	28065597
Intra	PTPRR	Q15256	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	33961781
Intra	PTPRR	Q15256	MAPK14	Homo sapiens	Q16539	Phosphatase Assay	10601328
Intra	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	Phosphatase Assay	10601328
Intra	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	IF	10601328
Intra	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

PTPRR Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81804	PCPTP1 Antibody (YA1549)	WB	Rat
HY-P81804A	PCPTP1 Antibody (YA1549)(PBS only)	WB	Rat

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 84a	DFNB84A Deafness, Autosomal Recessive 84 Autosomal Recessive Nonsyndromic Deafness 84a Dfnb84 Deafness, Autosomal Recessive 84a, With Vestibular Dysfunction Autosomal Recessive Deafness 84a Autosomal Recessive Deafness 84a With Vestibular Dysfunction Deafness, Autosomal Recessive, 84a Deafness Autosomal Recessive 84 Deafness Autosomal Recessive 84a With Vestibular Dysfunction Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 84 Deafness, Autosomal Recessive, Type 84a
Autosomal Recessive Nonsyndromic Deafness 70	Deafness, Autosomal Recessive 70 Autosomal Recessive Deafness 70 Dfnb70 Deafness, Autosomal Recessive, Type 70
Deafness, Autosomal Dominant 2a	DFNA2A Autosomal Dominant Nonsyndromic Deafness 2a Autosomal Dominant Deafness 2a Deafness, Autosomal Dominant, 2a Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 2a Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 2a Deafness, Autosomal Dominant, Type 2a
Deafness, Autosomal Dominant 50	DFNA50 Autosomal Dominant Nonsyndromic Deafness 50 Autosomal Dominant Deafness 50 Deafness, Autosomal Dominant, Type 50
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Deafness, Autosomal Recessive 12	DFNB12 Deafness, Autosomal Recessive 12, Modifier Of Autosomal Recessive Nonsyndromic Deafness 12 Autosomal Recessive Deafness 12 Deafness, Autosomal Recessive, 12 Congenital Neurosensory Deafness Autosomal Recessive 12 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 12 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 12 Deafness, Autosomal Recessive, Type 12
Autosomal Recessive Nonsyndromic Deafness	Deafness, Autosomal Recessive, Nonsyndromic
Autosomal Dominant Nonsyndromic Deafness	Autosomal Dominant Deafness
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-141800	MurA-IN-1	Inhibitor	99.32%	Unkown
HY-RS11448	PTPRR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22754	Ptprr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTPRR	VGNC	VGNC:76621
Felis catus	PTPRR	VGNC	VGNC:69180
Rattus norvegicus	PTPRR	RGD	RGD:620780
Canis familiaris	PTPRR	VGNC	VGNC:45197
Bos taurus	PTPRR	VGNC	VGNC:33557
Mus musculus	PTPRR	MGD	MGI:109559
Others	PTPRR	NCBI