Retro-1
Retro-1 is a toxin inhibitor. Retro-1 blocks the retrograde transport of STxB to the trans-Golgi network/Golgi. Retro-1 inhibits the cytotoxic effects of Ricin, bacterial toxins Stx1 and Stx2. Retro-1 can also substantially enhance the effectiveness of antisense and splice switching oligonucleotides.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 313683-81-7
- Fòrmula: C18H17BrN2O2
- Peso molecular:373.24
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
6.2 μM
Compound: Retro-1; 6, mixture of enantiomers, mixture of conformers (1:1)
|
Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in radiolabelled-methionine incorporation preincubated with cells for 20 mins followed by Stx1 addition and measured after 1 hr by s
Inhibition of Escherichia coli Stx1 in human HeLa cells assessed as stimulation of protein synthesis by measuring increase in radiolabelled-methionine incorporation preincubated with cells for 20 mins followed by Stx1 addition and measured after 1 hr by s
|
[PMID: 32648758] |
Chemical Information
-
No. CAS 313683-81-7
-
Peso molecular 373.24
-
Fòrmula C18H17BrN2O2
-
SMILES
O=C1NC2=CC=C(C=C2C(N(C1)C(CC)=O)C3=CC=CC=C3)Br
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Stechmann B, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42. [Content Brief]
[2]. Ming X, et al. The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides. Nucleic Acids Res. 2013 Apr 1;41(6):3673-87. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz