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Cat. No.: HY-184778

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Ethyl 2-fluorocinnamate

Ethyl 2-fluorocinnamate is a substituted ethyl cinnamate derivative with antifungal activity and weak sensitizing activity. Ethyl 2-fluorocinnamate inhibits mycelial growth of phytopathogenic fungi. Ethyl 2-fluorocinnamate can be used in studies related to plant fungal diseases.

For research use only. We do not sell to patients.

CAS No.: 348-13-0
Formula: C₁₁H₁₁FO₂
Molecular Weight:194.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ethyl 2-fluorocinnamate Chemical Structure

CAS No.: 348-13-0

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Ethyl 2-fluorocinnamate (compound A11) exhibits in vitro antifungal activity against Fusarium solani, Pyricularia grisea, Valsa mali, and Botryosphaeria dothidea with an average inhibition rate of 39.3% at 0.5 mM after 72 h of incubation^[1].
Ethyl 2-fluorocinnamate (compound 3b) is a weaker skin sensitizer than ethyl cinnamate, with an EC_1.5 of 44.0 μM, an EC₂ of 109.3 μM, an Imax of 2.8, and an IC₅₀ of 304.2 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 348-13-0
Molecular Weight 194.20
Formula C₁₁H₁₁FO₂
SMILES

O=C(/C=C/C1=C(F)C=CC=C1)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou K, et al. Bioactivity and structure-activity relationship of cinnamic acid esters and their derivatives as potential antifungal agents for plant protection. PloS one. 2017;12(4):e0176189. [Content Brief]

[2]. Charpentier J, et al. Effect of Fluorination on Skin Sensitization Potential and Fragrant Properties of Cinnamyl Compounds. Chemistry & biodiversity. 2018 Apr;15(4):e1800013. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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