Ethyl acetoacetate-d5
Based on 1 Customer Validation
Ethyl acetoacetate-d5 is the deuterium labeled Ethyl acetoacetate. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds. Ethyl acetoacetate is an inhibitor of bacterial biofilm.
For research use only. We do not sell to patients.
- Purity: 99.22%
- CAS No.: 55514-60-8
- Formula: C6H5D5O3
- Molecular Weight:135.17
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 55514-60-8
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Unlabeled Cas 141-97-9
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Appearance Liquid
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Molecular Weight 135.17
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Formula C6H5D5O3
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Color Colorless to light yellow
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SMILES
[2H]C([2H])([2H])C(C([2H])([2H])C(OCC)=O)=O
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Synonyms
Ethyl acetylacetate-d5; EAA-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
H2O : 50 mg/mL (369.90 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[4]. Iqbal S, et al. 2-Oxo-1,2,3,4-tetrahydropyrimidines Ethyl Esters as Potent β- Glucuronidase Inhibitors: One-pot Synthesis, In vitro and In silico Studies. Med Chem. 201814(8):818-830. [Content Brief]
[5]. Horne SM, et al. Acetoacetate and ethyl acetoacetate as novel inhibitors of bacterial biofilm. Lett Appl Microbiol. 2018 Apr66(4):329-339. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.3981 mL | 36.9905 mL | 73.9809 mL | 184.9523 mL |
| 5 mM | 1.4796 mL | 7.3981 mL | 14.7962 mL | 36.9905 mL | |
| 10 mM | 0.7398 mL | 3.6990 mL | 7.3981 mL | 18.4952 mL | |
| 15 mM | 0.4932 mL | 2.4660 mL | 4.9321 mL | 12.3302 mL | |
| 20 mM | 0.3699 mL | 1.8495 mL | 3.6990 mL | 9.2476 mL | |
| 25 mM | 0.2959 mL | 1.4796 mL | 2.9592 mL | 7.3981 mL | |
| 30 mM | 0.2466 mL | 1.2330 mL | 2.4660 mL | 6.1651 mL | |
| 40 mM | 0.1850 mL | 0.9248 mL | 1.8495 mL | 4.6238 mL | |
| 50 mM | 0.1480 mL | 0.7398 mL | 1.4796 mL | 3.6990 mL | |
| 60 mM | 0.1233 mL | 0.6165 mL | 1.2330 mL | 3.0825 mL | |
| 80 mM | 0.0925 mL | 0.4624 mL | 0.9248 mL | 2.3119 mL | |
| 100 mM | 0.0740 mL | 0.3699 mL | 0.7398 mL | 1.8495 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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