2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. EVs inducer-1

EVs inducer-1 is a release inducer of immunostimulatory extracellular vesicles (EVs). EVs inducer-1 inhibits tubulin polymerization. EVs inducer-1 enhances the release of immunostimulatory EVs by antigen-presenting cells, increases the release of EV particles from dendritic cells, and elevates CD63 reporter gene activity. EVs inducer-1 inhibits the viability of proliferating cells. EVs inducer-1 is applicable for research related to immune regulation.

For research use only. We do not sell to patients.

EVs inducer-1

EVs inducer-1 Chemical Structure

CAS No. : 710280-48-1

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EVs inducer-1 Related Antibodies

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Description

EVs inducer-1 is a release inducer of immunostimulatory extracellular vesicles (EVs). EVs inducer-1 inhibits tubulin polymerization. EVs inducer-1 enhances the release of immunostimulatory EVs by antigen-presenting cells, increases the release of EV particles from dendritic cells, and elevates CD63 reporter gene activity. EVs inducer-1 inhibits the viability of proliferating cells. EVs inducer-1 is applicable for research related to immune regulation[1][2].

In Vitro

EVs inducer-1 (Compound 1) (10 μM; 48 h) significantly enhances CD63-mediated EV release in human CD63 Tluc-CD9 EmGFP THP-1 reporter cells[1].
EVs inducer-1 (10 μM; 20 h) exhibits extremely low cytotoxicity in primary mBMDC and hPBMC, but inhibits the viability of Jurkat, Ramos, RAW264.7, NIH3T3 and C2C12 cells[1].
EVs inducer-1 (0-10 μM) dose-dependently inhibits tubulin polymerization in cell-free biochemical assays[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EVs inducer-1 Related Antibodies

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[1]

Cell Line: Jurkat, Ramos, RAW264.7, NIH3T3, C2C12 cells
Concentration: 10 μM
Incubation Time: 20 h
Result: Reduced the cells activity (10-70%).
Molecular Weight

355.41

Formula

C21H13N3OS
CAS No.
SMILES

C1(C=CC=C2)=C2C=CC=C1C3=NN=C(C4=CC(C5=CC=CS5)=CN=C4)O3
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Purity & Documentation
References
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EVs inducer-1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EVs inducer-1710280-48-1EVs inducer1EVs inducer 1Microtubule/TubulinEVs inducertubulinJurkat cellsRamos cellsRAW264.7 cellsNIH3T3 cellsC2C12 cellsInhibitorinhibitorinhibit

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