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Cat. No.: HY-149723

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Ferroptosis-IN-5

Ferroptosis-IN-5 (compound 9c) is a ferroptosis inhibitor with iron-chelating and reactive oxygen species (ROS) scavenging activities.

For research use only. We do not sell to patients.

CAS No.: 2991058-60-5
Formula: C₁₅H₁₃FN₂O₃
Molecular Weight:288.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ferroptosis-IN-5 Chemical Structure

CAS No.: 2991058-60-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ferroptosis-IN-5 (compound 9c) is a ferroptosis inhibitor with iron-chelating and reactive oxygen species (ROS) scavenging activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	EC₅₀	24.89 μM Compound: 9c	Protection against cisplatin-induced cytotoxicity in HEK293T cells assessed as cell viability measured after 24 to 48 hrs by MTT assay Protection against cisplatin-induced cytotoxicity in HEK293T cells assessed as cell viability measured after 24 to 48 hrs by MTT assay	[PMID: 37976709]
HT-22	EC₅₀	14.89 μM Compound: 9c	Anti-ferroptotic activity in erastin-induced ferroptosis in mouse HT-22 cells assessed as cell viability incubated for 24 hrs by MTT assay Anti-ferroptotic activity in erastin-induced ferroptosis in mouse HT-22 cells assessed as cell viability incubated for 24 hrs by MTT assay	[PMID: 37976709]

Chemical Information

CAS No. 2991058-60-5
Molecular Weight 288.27
Formula C₁₅H₁₃FN₂O₃
SMILES

FC1=CC=CC(/C=C/C(NN2C(C)=C(O)C(C=C2)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Changjun Zhang, et al. Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity. Eur J Med Chem. 2023 Nov 11:263:115945. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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