Ferroptosis inducer-11
Ferroptosis inducer-11 is a ferroptosis inducer. Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM and 0.48 μM, respectively. Ferroptosis inducer-11 strongly suppresses GPX4 enzymatic activity with an IC50 of 1.86 μM. Ferroptosis inducer-11 induces ferroptosis, as well as increases intracellular lipid ROS, malondialdehyde (MDA), and Fe2+ levels, while decreasing glutathione (GSH) levels in colon cancer cells. Ferroptosis inducer-11 can be used for the study of colon cancer.
For research use only. We do not sell to patients.
- Formula: C30H36N2O8
- Molecular Weight:552.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GPX4 |
GPX4 1.86 μM (IC50) |
Ferroptosis inducer-11 (Compound 30) (0.25-1 μM, 24 h) shows potent inhibitory activity on colony formation of HCT-116 colon cancer cells[1].
Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM and 0.48 μM, respectively[1].
Ferroptosis inducer-11 (0.25-1 μM, 6-24 h) significantly increases lipid ROS levels in a time- and dose-dependent manner in HCT-116 cells[1].
Ferroptosis inducer-11 (0.25-1 μM, 12 h) dose-dependently elevates MDA levels, increases intracellular Fe2+ levels and reduces GSH levels in HCT-116 cells[1].
Ferroptosis inducer-11 shows potent GPX4 inhibitory activity, with an IC50 value of 1.86 μM[1].
Ferroptosis inducer-11 (0.25-1 μM, 6-24 h) downregulates GPX4 protein expression in a time- and dose-dependent manner in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 cells
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Concentration:0.25, 0.5. 1 μM
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Incubation Time:6, 12, 24 h
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Result:Downregulated GPX4 protein expression in a time- and dose-dependent manner in HCT-116 cells[1].
Chemical Information
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Molecular Weight 552.62
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Formula C30H36N2O8
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SMILES
O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@@H]2[C@](/C=C/C=C(C)/C(N3CCN(C(C#C)=O)CC3)=O)(C)O4)(CC2)C4=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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