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Cat. No.: HY-156410

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FLT3-IN-23

FLT3-IN-23 (compound 15) is an inhibitor of JFMS-like tyrosine kinase 3 (FLT3) with an IC₅₀ of 7.42 nM. FLT3-IN-23 has antiproliferative activities against BaF3 cells carrying various FLT3-TKD and FLT3-ITD-TKD mutations.

For research use only. We do not sell to patients.

CAS No.: 2489528-97-2
Formula: C₂₂H₂₈F₃N₅O₂
Molecular Weight:451.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

FLT3-IN-23 Chemical Structure

CAS No.: 2489528-97-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.91 nM Compound: 15	Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD mutant assessed as inhibition of cell growth Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD mutant assessed as inhibition of cell growth	[PMID: 37838343]
BaF3	IC₅₀	0.94 nM Compound: 15	Antiproliferative activity against mouse BaF3 cells harboring FLT3-D835F mutant assessed as inhibition of cell growth Antiproliferative activity against mouse BaF3 cells harboring FLT3-D835F mutant assessed as inhibition of cell growth	[PMID: 37838343]
BaF3	IC₅₀	0.95 nM Compound: 15	Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-D835Y mutant assessed as inhibition of cell growth Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-D835Y mutant assessed as inhibition of cell growth	[PMID: 37838343]
BaF3	IC₅₀	0.98 nM Compound: 15	Antiproliferative activity against mouse BaF3 cells harboring FLT3-D835V mutant assessed as inhibition of cell growth Antiproliferative activity against mouse BaF3 cells harboring FLT3-D835V mutant assessed as inhibition of cell growth	[PMID: 37838343]
BaF3	IC₅₀	4.2 nM Compound: 15	Antiproliferative activity against mouse BaF3 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth Antiproliferative activity against mouse BaF3 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth	[PMID: 37838343]
HeLa	IC₅₀	5782.67 nM Compound: 15	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth	[PMID: 37838343]
MCF7	IC₅₀	4982 nM Compound: 15	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth	[PMID: 37838343]
MM1.S	IC₅₀	2245.33 nM Compound: 15	Antiproliferative activity against human MM1.S cells assessed as inhibition of cell growth Antiproliferative activity against human MM1.S cells assessed as inhibition of cell growth	[PMID: 37838343]
MOLM-13	IC₅₀	10.55 nM Compound: 15	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth	[PMID: 37838343]
MV4-11	IC₅₀	0.83 nM Compound: 15	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth	[PMID: 37838343]
PBMC	IC₅₀	7861.33 nM Compound: 15	Antiproliferative activity against human PBMC cells assessed as inhibition of cell growth Antiproliferative activity against human PBMC cells assessed as inhibition of cell growth	[PMID: 37838343]

Chemical Information

CAS No. 2489528-97-2
Molecular Weight 451.49
Formula C₂₂H₂₈F₃N₅O₂
SMILES

CC1(COC1)COC2=CC=C(C=C2)NC3=NC=C(C(N[C@@H]4CC[C@H](N)CC4)=N3)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xuanmin Lian, et al. Design, synthesis and biological evaluation of 2-aminopyrimidine derivatives as potent FLT3 inhibitors. Bioorg Med Chem Lett. 2023, 23. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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