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Cat. No.: HY-163068

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FLT3-IN-24

FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase with an IC₅₀ of 7.94 nM. FLT3-IN-24 has cell antiproliferative effects.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₀N₆O₂S
Molecular Weight:444.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

FLT3-IN-24 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase with an IC₅₀ of 7.94 nM. FLT3-IN-24 has cell antiproliferative effects^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>1000 nM Compound: 24	Cytotoxicity against HEK293 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay	[PMID: 38056299]
K562	IC₅₀	>1000 nM Compound: 24	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay	[PMID: 38056299]
MDA-MB-231	IC₅₀	>1000 nM Compound: 24	Antiproliferative activity against human MDA-MB-231 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay Antiproliferative activity against human MDA-MB-231 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay	[PMID: 38056299]
MOLM-14	IC₅₀	3.16 nM Compound: 24	Antiproliferative activity against human MOLM-14 cells harboring FLT3-D835Y mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay Antiproliferative activity against human MOLM-14 cells harboring FLT3-D835Y mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay	[PMID: 38056299]
MOLM-14	IC₅₀	4.55 nM Compound: 24	Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay	[PMID: 38056299]
MOLM-14	IC₅₀	8.34 nM Compound: 24	Antiproliferative activity against human MOLM-14 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay Antiproliferative activity against human MOLM-14 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay	[PMID: 38056299]

Chemical Information

Molecular Weight 444.51
Formula C₂₃H₂₀N₆O₂S
SMILES

CS(=O)(C1=CC=C(C=C1)NC2=CC=CC(C3=CN=C4C=C(C=CN34)C5=CN(C)N=C5)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang X, et al.An imidazo [1, 2-a] pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L[J]. European Journal of Medicinal Chemistry, 2023: 115977.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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