2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. FLT3-IN-24

FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase with an IC50 of 7.94 nM. FLT3-IN-24 has cell antiproliferative effects.

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FLT3-IN-24

FLT3-IN-24 Chemical Structure

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FLT3-IN-24 Related Antibodies

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Description

FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase with an IC50 of 7.94 nM. FLT3-IN-24 has cell antiproliferative effects[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 1000 nM
Compound: 24
Cytotoxicity against HEK293 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Cytotoxicity against HEK293 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
[PMID: 38056299]
K562 IC50
> 1000 nM
Compound: 24
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
[PMID: 38056299]
MDA-MB-231 IC50
> 1000 nM
Compound: 24
Antiproliferative activity against human MDA-MB-231 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MDA-MB-231 cells lacking FLT3 activating mutations assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
[PMID: 38056299]
MOLM-14 IC50
3.16 nM
Compound: 24
Antiproliferative activity against human MOLM-14 cells harboring FLT3-D835Y mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MOLM-14 cells harboring FLT3-D835Y mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
[PMID: 38056299]
MOLM-14 IC50
4.55 nM
Compound: 24
Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
[PMID: 38056299]
MOLM-14 IC50
8.34 nM
Compound: 24
Antiproliferative activity against human MOLM-14 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MOLM-14 cells harboring FLT3-F691L mutant assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
[PMID: 38056299]
Molecular Weight

444.51

Formula

C23H20N6O2S
SMILES

CS(=O)(C1=CC=C(C=C1)NC2=CC=CC(C3=CN=C4C=C(C=CN34)C5=CN(C)N=C5)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FLT3-IN-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-24FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Acute myeloid leukemiaAMLFLT3-ITDMutationInhibitorinhibitorinhibit

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