Fluorofolin
Based on 1 Customer Validation
Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5 nM. Fluorofolin exhibits significant activity against P. aeruginosa.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 2757070-32-7
- Formula: C16H13FN6
- Molecular Weight:308.31
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Metabolism/Protease Compound Library
HY-L012
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Antibacterial Compound Library
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Biological Activity
Fluorofolin exhibits potent activity against PP. aeruginosa PA14 (MIC of 3.1 µg/ml). Fluorofolin has broad-spectrum antibiotic activity, as it is also capable of inhibiting growth of two other strains of PP. aeruginosa, PA01 and ATTC 27853[1].
In the presence of thymine supplementation, Fluorofolin activity is selective for P. aeruginosa[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2757070-32-7
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Appearance Solid
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Molecular Weight 308.31
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Formula C16H13FN6
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Color White to off-white
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SMILES
NC1=NC(N)=NC2=C1C(C=CN3CC4=CC=NC(F)=C4)=C3C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (324.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2435 mL | 16.2174 mL | 32.4349 mL | 81.0872 mL |
| 5 mM | 0.6487 mL | 3.2435 mL | 6.4870 mL | 16.2174 mL | |
| 10 mM | 0.3243 mL | 1.6217 mL | 3.2435 mL | 8.1087 mL | |
| 15 mM | 0.2162 mL | 1.0812 mL | 2.1623 mL | 5.4058 mL | |
| 20 mM | 0.1622 mL | 0.8109 mL | 1.6217 mL | 4.0544 mL | |
| 25 mM | 0.1297 mL | 0.6487 mL | 1.2974 mL | 3.2435 mL | |
| 30 mM | 0.1081 mL | 0.5406 mL | 1.0812 mL | 2.7029 mL | |
| 40 mM | 0.0811 mL | 0.4054 mL | 0.8109 mL | 2.0272 mL | |
| 50 mM | 0.0649 mL | 0.3243 mL | 0.6487 mL | 1.6217 mL | |
| 60 mM | 0.0541 mL | 0.2703 mL | 0.5406 mL | 1.3515 mL | |
| 80 mM | 0.0405 mL | 0.2027 mL | 0.4054 mL | 1.0136 mL | |
| 100 mM | 0.0324 mL | 0.1622 mL | 0.3243 mL | 0.8109 mL |
Fluorofolin Related Classifications
HY-162475 Related Classifications
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