2. Metabolic Enzyme/Protease Anti-infection
  3. Dihydrofolate reductase (DHFR) Bacterial
  4. Fluorofolin

Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5 nM. Fluorofolin exhibits significant activity against P. aeruginosa.

For research use only. We do not sell to patients.

Fluorofolin

Fluorofolin Chemical Structure

CAS No. : 2757070-32-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Fluorofolin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5 nM. Fluorofolin exhibits significant activity against P. aeruginosa[1].

In Vitro

Fluorofolin exhibits potent activity against PP. aeruginosa PA14 (MIC of 3.1 µg/ml). Fluorofolin has broad-spectrum antibiotic activity, as it is also capable of inhibiting growth of two other strains of PP. aeruginosa, PA01 and ATTC 27853[1].
In the presence of thymine supplementation, Fluorofolin activity is selective for P. aeruginosa[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fluorofolin Related Antibodies
In Vivo

In mice, Fluorofolin displays favourable plasma protein binding (71.7% bound, 91.9% recovery). Upon oral administration, fluorofolin achieved a peak concentration of 4.0 μg/mL with a half-life of 12.1 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

308.31

Formula

C16H13FN6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(N)=NC2=C1C(C=CN3CC4=CC=NC(F)=C4)=C3C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (324.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2435 mL 16.2174 mL 32.4349 mL
5 mM 0.6487 mL 3.2435 mL 6.4870 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

SDS (251 KB)

COA (247 KB) HNMR (264 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2435 mL 16.2174 mL 32.4349 mL 81.0872 mL
5 mM 0.6487 mL 3.2435 mL 6.4870 mL 16.2174 mL
10 mM 0.3243 mL 1.6217 mL 3.2435 mL 8.1087 mL
15 mM 0.2162 mL 1.0812 mL 2.1623 mL 5.4058 mL
20 mM 0.1622 mL 0.8109 mL 1.6217 mL 4.0544 mL
25 mM 0.1297 mL 0.6487 mL 1.2974 mL 3.2435 mL
30 mM 0.1081 mL 0.5406 mL 1.0812 mL 2.7029 mL
40 mM 0.0811 mL 0.4054 mL 0.8109 mL 2.0272 mL
50 mM 0.0649 mL 0.3243 mL 0.6487 mL 1.6217 mL
60 mM 0.0541 mL 0.2703 mL 0.5406 mL 1.3515 mL
80 mM 0.0405 mL 0.2027 mL 0.4054 mL 1.0136 mL
100 mM 0.0324 mL 0.1622 mL 0.3243 mL 0.8109 mL
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Fluorofolin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluorofolin2757070-32-7Dihydrofolate reductase (DHFR)BacterialDHFR inhibitorP. aeruginosaMexCD-OprJMexEF-OprNInhibitorinhibitorinhibit

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