2. Anti-infection
  3. CMV
  4. Fomivirsen

Fomivirsen (ISIS-2922) is an antisense phosphorothioate oligonucleotide. Fomivirsen is an antiviral reagent used in research on cytomegalovirus (CMV) retinitis. Fomivirsen binds to and degrades the mRNA of CMV immediate-early 2 protein, thereby inhibiting viral proliferation. Fomivirsen can be used in research related to cytomegalovirus retinitis and cytomegalovirus diseases.

For research use only. We do not sell to patients.

DNA, d(P-thio)(G-C-G-T-T-T-G-C-T-C-T-T-C-T-T-C-T-T-G-C-G)

Fomivirsen Chemical Structure

CAS No. : 144245-52-3

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Based on 2 publication(s) in Google Scholar

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Fomivirsen Related Antibodies

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Description

Fomivirsen (ISIS-2922) is an antisense phosphorothioate oligonucleotide. Fomivirsen is an antiviral reagent used in research on cytomegalovirus (CMV) retinitis. Fomivirsen binds to and degrades the mRNA of CMV immediate-early 2 protein, thereby inhibiting viral proliferation. Fomivirsen can be used in research related to cytomegalovirus retinitis and cytomegalovirus diseases[1][2].

In Vitro

Fomivirsen (0.1-10 μM; overnight) potently inhibits the replication of the HCMV strain AD169 in NHDF cells, with a mean EC50 of 0.37 μM[1].
Fomivirsen (1.2-10 μM; overnight) reduces the total infectious HCMV titer by 2 log units at a concentration of 2.2 μM, and reduces the intracellular titer by >3 log units at 10 μM, in NHDF cells[1].
Fomivirsen (0.1-1 μM; overnight pre-treatment) inhibits HCMV plaque formation in NHDF cells; for the AD169 strain, its IC70 is 0.1 μM, and for the Towne strain, its EC50 is 0.3 μM[1].
Fomivirsen (0.25-8 μM; 15-24 h) reduces the protein expression of HCMV IE1 and IE2 in NHDF cells in a dose-dependent manner[1].
Fomivirsen inhibits HCMV with an EC50 of 0.1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fomivirsen Related Antibodies

Western Blot Analysis[1]

Cell Line: NHDF cells infected with HCMV (MOI 0.5 PFU per cell)
Concentration: 0.25-8 μM
Incubation Time: Overnight
Result: Reduced steady-state levels of both 72 kDa and 86 kDa IE polypeptides in a dose-dependent manner.
Significantly reduced polypeptide levels at 0.5 μM.

Immunofluorescence[1]

Cell Line: NHDF cells infected with HCMV (MOI 3 PFU per cell)
Concentration: 1 μM
Incubation Time: 15-20 h
Result: Reduced the proportion of HCMV-infected cells exhibiting nuclear immunofluorescence to <10% (from >70% in untreated cells).
Reduced the intensity of fluorescence in positive cells.
Parmacokinetics
Species Dose Route T1/2
Rabbit[2] 66 μg i.v.t 62 h
Molecular Weight

6682.40

Formula

C204H263N63O114P20S20
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Fomivirsen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Fomivirsen Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fomivirsen144245-52-3ISIS-2922ISIS2922ISIS 2922CMVCytomegalovirusantisense phosphorothioate oligonucleotideretinitisNHDF cells
Inhibitorinhibitorinhibit

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