country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-164414

Copy Link Print Information

CCT129254

(Synonyms: AT 11854)

CCT129254 is a potent Akt inhibitor. CCT129254 reduces the motility of melanoma cells in vivo.

For research use only. We do not sell to patients.

CAS No.: 885500-12-9
Formula: C₁₉H₂₁ClN₆O
Molecular Weight:384.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CCT129254 Chemical Structure

CAS No.: 885500-12-9

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CCT129254 is a potent Akt inhibitor. CCT129254 reduces the motility of melanoma cells in vivo^[1].

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	5235 nM Compound: 3	Inhibition of human ERG expressed in CHO cells by ionworks assay Inhibition of human ERG expressed in CHO cells by ionworks assay	[PMID: 23394218]
MDA-MB-468	IC₅₀	328 nM Compound: 3	Inhibition of Akt in human MDA-MB-468 cells assessed as inhibition of GSK3beta phosphorylation after 2 hrs by laser scanning cytometry Inhibition of Akt in human MDA-MB-468 cells assessed as inhibition of GSK3beta phosphorylation after 2 hrs by laser scanning cytometry	[PMID: 23394218]
PC-3M	IC₅₀	>50 nM Compound: 21, CCT129524	Antiproliferative activity against human PC3M cells after 96 hrs by SRB assay Antiproliferative activity against human PC3M cells after 96 hrs by SRB assay	[PMID: 20151677]
U-87MG ATCC	GI₅₀	0.93 nM Compound: 21, CCT129524	Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA	[PMID: 20151677]
U-87MG ATCC	IC₅₀	17 nM Compound: 21, CCT129524	Antiproliferative activity against human U87MG cells after 96 hrs by SRB assay Antiproliferative activity against human U87MG cells after 96 hrs by SRB assay	[PMID: 20151677]

Chemical Information

CAS No. 885500-12-9
Molecular Weight 384.86
Formula C₁₉H₂₁ClN₆O
SMILES

ClC1=CC=C(CNC(C2(N)CCN(C3=NC=NC4=C3C=CN4)CC2)=O)C=C1
Synonyms

AT 11854
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gandalovičová A, et al. Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges. Trends Cancer. 2017 Jun;3(6):391-406. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

CCT129254

All Akt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CCT129254 Related Classifications

HY-164414 Related Classifications