YF-452
YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1951466-83-3
- Formula: C24H26BrN3O
- Molecular Weight:452.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Biological Activity
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VEGFR2 |
Chemical Information
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CAS No. 1951466-83-3
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Molecular Weight 452.39
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Formula C24H26BrN3O
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SMILES
BrC1=CC=C(CN(C2=C3C=CC=C2)C4=C3CCN(C4)C(CN5CCCC5)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YF-452 Related Classifications
HY-120200 Related Classifications
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