NVS-PAK1-C
Based on 1 publication(s) in Google Scholar
NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM).
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- Pureté : 99.2%
- CAS No.: 2250019-95-3
- Formule: C22H23ClF3N5O
- Masse moléculaire:465.90
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) NVS-PAK1-C
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Activité biologique
Description
IC50 & Target
[1]|
PAK1 0.007 μM (Kd) |
PAK2 0.4 μM (Kd) |
PAK1 5 nM (IC50) |
PAK2 270 nM (IC50) |
In Vitro
NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50=0.21 µM in Su86.86 cells in which PAK2 is downregulated[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2250019-95-3
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Appearance Solid
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Masse moléculaire 465.90
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Formule C22H23ClF3N5O
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Color White to off-white
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SMILES
O=C(N1C[C@@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C4=CC=C(Cl)C=C42)CC1)N(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability. [Abstract]2024 Oct 22:2024.10.22.619411. PMID: 39484617
Solvant et solubilité
In Vitro:
DMSO : ≥ 50 mg/mL (107.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1464 mL | 10.7319 mL | 21.4638 mL | 53.6596 mL |
| 5 mM | 0.4293 mL | 2.1464 mL | 4.2928 mL | 10.7319 mL | |
| 10 mM | 0.2146 mL | 1.0732 mL | 2.1464 mL | 5.3660 mL | |
| 15 mM | 0.1431 mL | 0.7155 mL | 1.4309 mL | 3.5773 mL | |
| 20 mM | 0.1073 mL | 0.5366 mL | 1.0732 mL | 2.6830 mL | |
| 25 mM | 0.0859 mL | 0.4293 mL | 0.8586 mL | 2.1464 mL | |
| 30 mM | 0.0715 mL | 0.3577 mL | 0.7155 mL | 1.7887 mL | |
| 40 mM | 0.0537 mL | 0.2683 mL | 0.5366 mL | 1.3415 mL | |
| 50 mM | 0.0429 mL | 0.2146 mL | 0.4293 mL | 1.0732 mL | |
| 60 mM | 0.0358 mL | 0.1789 mL | 0.3577 mL | 0.8943 mL | |
| 80 mM | 0.0268 mL | 0.1341 mL | 0.2683 mL | 0.6707 mL | |
| 100 mM | 0.0215 mL | 0.1073 mL | 0.2146 mL | 0.5366 mL |
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