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Cat. No.: HY-P11889

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Tyrocidine A

Tyrocidine A is an amphipathic cyclic decapeptide natural product, as well as a membrane-disrupting agent and an antibacterial agent. Tyrocidine A exhibits moderate activity against Gram-positive bacteria. Tyrocidine A can insert into bacterial cell membranes, form porous channels, disrupt membrane integrity and induce bacterial cell death. Tyrocidine A can be used in studies related to bacterial infections.

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CAS No.: 1481-70-5
Formule: C₆₆H₈₇N₁₃O₁₃
Masse moléculaire:1270.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

Tyrocidine A Chemical Structure

CAS No.: 1481-70-5

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Tyrocidine A (overnight treatment) exhibits moderate antibacterial activity against Gram-positive strains (MIC 16-32 μg/mL) at a calcium ion concentration of 25 mg/L, while it shows no activity against Gram-negative E. coli ATCC 25922 (MIC >128 μg/mL); its activity decreases moderately at a calcium ion concentration of 50 mg/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1481-70-5
Masse moléculaire 1270.48
Formule C₆₆H₈₇N₁₃O₁₃
SMILES

O=C1N2[C@](CCC2)([H])C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1CC3=CC=CC=C3)=O)CC(C)C)=O)CCCN)=O)C(C)C)=O)CC4=CC=C(C=C4)O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O
Sequence

cyclo(Asn-Gln-Tyr-Val-Orn-Leu-DPhe-Pro-Phe-DPhe)
Sequence Shortening

cyclo(NQYV-Orn-L-DPhe-PF-DPhe)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Marques MA, et al.. Development of Tyrocidine A analogues with improved antibacterial activity. Bioorganic & medicinal chemistry. 2007 Nov 01;15(21):6667-77. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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