2. Neuronal Signaling
  3. Monoamine Oxidase
  4. FTEAA

FTEAA is a 4-styrylpiperidine inhibitor. FTEAA exhibits potent inhibitory effect towards both monoamine oxidase with IC50s of 0.52 μM (MAO-A), 1.02 μM (MAO-B), respectively. MAO inhibitors can be used for cardiovascular, neurological and oncological disorders research.

For research use only. We do not sell to patients.

FTEAA Chemical Structure

FTEAA Chemical Structure

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FTEAA Related Antibodies

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MAO-A MAO-B

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Description

FTEAA is a 4-styrylpiperidine inhibitor. FTEAA exhibits potent inhibitory effect towards both monoamine oxidase with IC50s of 0.52 μM (MAO-A), 1.02 μM (MAO-B), respectively. MAO inhibitors can be used for cardiovascular, neurological and oncological disorders research[1][2].

IC50 & Target

MAO-A

0.52 μM (IC50)

MAO-B

1.02 μM (IC50)

In Vitro

MAO-A and MAO-B act function to lower central nervous system (CNS) concentration of monoamines, regulate the amount and activity of available monoamines[1].
If dopamine levels are too high, MAO levels will increase to compensate. If serotonin levels are too low, then MAO activity will decrease to leave adequate serotonin supplies for the CNS to function optimally[1].
FTEAA inhibits MAO-A and MAO-B with micromolar scale IC50s of 0.52 and 1.02 μM, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FTEAA Related Antibodies
In Vivo

FTEAA exhibits total clearance of 0.446 log/mL/min/kg, and the tolerable dose is prescribed to be 0.513 log mg/kg/day[2].
Predicted Pharmacokinetic Analysis of FTEAA[2]

Intestinal Absorption (%) Total Clearance (log/mL/min/kg) Max. Tolerable Dose(log mg/kg/day) RO5 Rulea
95.664 0.812 0.493 yes
a : the molecular weight of the drug must not exceed 500 g/mol, hydrogen bond donors must be under five, hydrogen bond acceptors must essentially be less than ten, its lipophilicity (log P) should not cross the digit five, and the number of rotatable bonds must be less than 10.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

646.57

Formula

C34H26F8N2O2
SMILES

O=C(C1=C(NC2=CC=C(F)C=C2)CC(C3=CC=C(C(F)(F)F)C=C3)N(C4=CC=C(F)C=C4)C1C5=CC=C(C(F)(F)F)C=C5)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FTEAA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTEAAMonoamine OxidaseMAOcardiovascularneurologicaloncological disorders1-Propargyl-4-styrylpiperidine-like analoguesdopamine levelsserotonin levelsCNScentral nervous systemInhibitorinhibitorinhibit

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