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  3. G43

G43 

Cat. No.: HY-155715
Handling Instructions

G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study.

For research use only. We do not sell to patients.

G43 Chemical Structure

G43 Chemical Structure

CAS No. : 690693-02-8

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Description

G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study[1][2].

In Vitro

G43 (16 h) inhibits more than 85% of S. mutans biofilm at 12.5 μM[1].
G43 (25 μM, 24 h) reduces the glucan production by the glucosyltransferase (Gtfs), and consistently inhibits the activity of both GtfB and GtfC with 80% inhibition of both enzymes[1].
G43 (up to 25 μM, 24 h) shows no significant difference on expression of gtfs (gtfB, gtfC and gtfD) in S. mutans. UA159 cells[1].
G43 (50 μM, 24-48 h) reduces the biofilm formation by decreasing the production of Water-insoluble extracellular polysaccharide in wild-type S. mutans[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: S. mutans. UA159 cells
Concentration: 3.125, 6.25, 12, 25 μM
Incubation Time: 24 h
Result: Showed no significant difference on expression of gtfs (gtfB, gtfC and gtfD).
In Vivo

G43 (100 µM twice daily for 4 weeks, topically administration) reduces S. mutans virulence in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The rat model of dental caries infected with S. mutans UA159[1]
Dosage: 100 µM twice daily for 4 weeks
Administration: Topically administration
Result: Reduced the buccal, sulcal, and proximal surface caries scores, but did not lose weight over the course of the study.
Molecular Weight

341.34

Formula

C16H11N3O4S

CAS No.
SMILES

O=C(C1=CC2=C(S1)C=CC([N+]([O-])=O)=C2)NC3=CC=CC=C3C(N)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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