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Cat. No.: HY-P12391A

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Gap26M TFA

Gap26M TFA is a Connexin 43 (Cx43) mimetic peptide. Gap26M TFA blocks gap junction intercellular communication in a connexin-nonspecific, non-selective manner. Gap26M TFA exhibits differential effects on gap junction function between static cells and migrating cells. Gap26M TFA promotes cell migration toward the wound edge and enhances wound closure.

For research use only. We do not sell to patients.

Formula: C₇₂H₁₀₉N₁₉O₂₀S·xC₂HF₃O₂
Molecular Weight:1592.82 (free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

Gap26M TFA Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Gap26M TFA increases keratinocyte and fibroblast migration rates in in vitro migration assays and is non-Cx43-specific^[1].
Gap26M (10-100 μM) TFA reduces gap-junction dye transfer in primary skin fibroblasts, with activity at 50 μM^[2].
Gap26M (100 μM; peptide replaced every 12 h) TFA increases wound-closure rates in primary keratinocytes and fibroblasts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 1592.82 (free base)
Formula C₇₂H₁₀₉N₁₉O₂₀S·xC₂HF₃O₂
SMILES

O=C(N[C@@H](C(C)C)C(N[C@@H](CS)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C.O=C(O)C(F)(F)F.[x]
Sequence

Ac-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg
Sequence Shortening

Ac-VCYDKSFPISHVR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang XF, et al. Connexin 43: Key roles in the skin. Biomedical reports. 2017 Jun;6(6):605-611.

[2]. Wright C S,, et al. Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro[J]. Wound Repair and Regeneration, 2009, 17(2): 240-249.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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