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Cat. No.: HY-W076740

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8-Bromoadenine

(Synonyms: 8-Bromo-9H-purin-6-amine)

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8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium.

For research use only. We do not sell to patients.

Purity: 98.92%
CAS No.: 6974-78-3
Formula: C₅H₄BrN₅
Molecular Weight:214.02

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

8-Bromoadenine Chemical Structure

CAS No.: 6974-78-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

8-Bromoadenine (0.1 mM; 30-90 min) inhibits DNA single-strand break repair in HeLa-M cell monolayer cultures. And after γ irradiation, the quality of DNA synthesized by cells is lower than that of DNA synthesized by cells without purine addition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6974-78-3
Appearance Solid
Molecular Weight 214.02
Formula C₅H₄BrN₅
Color Off-white to yellow
SMILES

BrC1=NC2=C(N1)C(N)=NC=N2
Synonyms

8-Bromo-9H-purin-6-amine
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

0.1 M NaOH : 0.2 mg/mL (0.93 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tkalich A V, et al. Effect of 8-bromoadenine on DNA repair[J]. Tsitologiia, 1980, 22(8): 994-997.

[2]. Radioactively marked nucleic acid units. German Democratic Republic, DD106383 A1 1974-06-12.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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8-Bromoadenine

MCE Kinase Hinge Binder Fragment Library

All DNA/RNA Synthesis Isoforms