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Cat. No.: HY-168347

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TH152

TH152 is a reversible, pan ligand for LC3/GABARAP with a K_D of 2 µM. LC3/GABARAP is an autophagy associated protein.

For research use only. We do not sell to patients.

CAS No.: 1622917-95-6
Formula: C₂₂H₂₃ClN₄O₄S₂
Molecular Weight:507.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

TH152 Chemical Structure

CAS No.: 1622917-95-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TH152 is a reversible, pan ligand for LC3/GABARAP with a K_D of 2 µM. LC3/GABARAP is an autophagy associated protein^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 18	Inhibition of mPGES-1 in human A549 cells microsomes assessed as reduction in PGE2 formation by RP-HPLC assay Inhibition of mPGES-1 in human A549 cells microsomes assessed as reduction in PGE2 formation by RP-HPLC assay	[PMID: 25037914]
PMNL	IC₅₀	>10 μM Compound: 18	Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC based cell-free assay Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC based cell-free assay	[PMID: 25037914]
PMNL	IC₅₀	>10 μM Compound: 18	Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC method Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC method	[PMID: 25037914]

Chemical Information

CAS No. 1622917-95-6
Molecular Weight 507.03
Formula C₂₂H₂₃ClN₄O₄S₂
SMILES

OC(C1=CC=C(C=C1)C2=CSC(NC3=CC(Cl)=NC(SC(CCCCCC)C(O)=O)=N3)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schwalm MP, et al., Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets. Nat Commun. 2024 Nov 25;15(1):10204. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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