2-AEMP
2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA(A)-ρ1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC(50) value of 18 μM, compared to 7 μM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity.
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- No. CAS: 321882-95-5
- Fòrmula: C3H10NO3P
- Peso molecular:139.09
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | IC50 |
11.1 μM
Compound: 4a
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Antagonist activity at GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as reduction of GABA-induced chloride ion currents
Antagonist activity at GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as reduction of GABA-induced chloride ion currents
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[PMID: 17467985] |
Chemical Information
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No. CAS 321882-95-5
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Peso molecular 139.09
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Fòrmula C3H10NO3P
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SMILES
CP(OCCN)(O)=O
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Synonyms
2-Aminoethyl methylphosphonate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-AEMP Related Classifications
HY-129907 Related Classifications
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