2-Hydroxyacetaldehyde
2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways.
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- No. CAS: 141-46-8
- Fòrmula: C2H4O2
- Peso molecular:60.05
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Help & FAQs
Actividad biológica
2-Hydroxyacetaldehyde (80 mM; 2.5-21 h at 37°C) rapidly modifies lysine residues on human LDL[1].
2-hydroxyacetaldehyde-modified human LDL (100 μg/mL) does not compete with native LDL for LDL receptors on cultured normal human fibroblasts, resulting in a degradation rate of 94% relative to the no-competitor control[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 141-46-8
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Peso molecular 60.05
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Fòrmula C2H4O2
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SMILES
OCC=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Hydroxyacetaldehyde Related Classifications
HY-28911 Related Classifications
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