LG-100064
Based on 1 publication(s) in Google Scholar
LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.55%
- No. CAS: 153559-46-7
- Fòrmula: C23H26O3
- Peso molecular:350.45
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) LG-100064
More
Actividad biológica
EC50: 330 nM (RXRα), 200 nM (RXRβ), 260 nM (RXRγ)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CV-1 | EC50 |
1604 nM
Compound: 1
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Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma
Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma
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[PMID: 10052980] |
| CV-1 | EC50 |
2068 nM
Compound: 1
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Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta
Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta
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[PMID: 10052980] |
| CV-1 | EC50 |
213 nM
Compound: 1
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Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-beta
Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-beta
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[PMID: 10052980] |
| CV-1 | EC50 |
246 nM
Compound: 1
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Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-gamma
Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-gamma
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[PMID: 10052980] |
| CV-1 | EC50 |
279 nM
Compound: 1
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Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-alpha
Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-alpha
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[PMID: 10052980] |
| CV-1 | EC50 |
4 nM
Compound: 1
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Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha
Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha
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[PMID: 10052980] |
| CV-1 | EC50 |
>10000 nM
Compound: 5b
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Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells
Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells
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[PMID: 8071941] |
| CV-1 | EC50 |
>10000 nM
Compound: 5b
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Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells
Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells
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[PMID: 8071941] |
| CV-1 | EC50 |
213 nM
Compound: 5b
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Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells
Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells
|
[PMID: 8071941] |
| CV-1 | EC50 |
246 nM
Compound: 5b
|
Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells
Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells
|
[PMID: 8071941] |
| CV-1 | EC50 |
379 nM
Compound: 5b
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Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells
Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells
|
[PMID: 8071941] |
| CV-1 | EC50 |
>10000 nM
Compound: 5b
|
Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells
Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells
|
[PMID: 8071941] |
LG-100064 (3-Methyl-TTNCB) is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ. LG-100064 shows no effect on RARα/β/γ (EC50, >10000 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 153559-46-7
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Appearance Solid
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Peso molecular 350.45
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Fòrmula C23H26O3
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(C(C2=C(C)C=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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J Exp Clin Cancer Res
GSTK1 suppresses HCC aggravation via L-carnitine metabolism by PGAM5/DRP1 complex-mediated mitochondrial quality control. [Abstract]2025 Nov 24;45(1):1. PMID: 41276823
Solvente y solubilidad
DMSO : 50 mg/mL (142.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8535 mL | 14.2674 mL | 28.5347 mL | 71.3369 mL |
| 5 mM | 0.5707 mL | 2.8535 mL | 5.7069 mL | 14.2674 mL | |
| 10 mM | 0.2853 mL | 1.4267 mL | 2.8535 mL | 7.1337 mL | |
| 15 mM | 0.1902 mL | 0.9512 mL | 1.9023 mL | 4.7558 mL | |
| 20 mM | 0.1427 mL | 0.7134 mL | 1.4267 mL | 3.5668 mL | |
| 25 mM | 0.1141 mL | 0.5707 mL | 1.1414 mL | 2.8535 mL | |
| 30 mM | 0.0951 mL | 0.4756 mL | 0.9512 mL | 2.3779 mL | |
| 40 mM | 0.0713 mL | 0.3567 mL | 0.7134 mL | 1.7834 mL | |
| 50 mM | 0.0571 mL | 0.2853 mL | 0.5707 mL | 1.4267 mL | |
| 60 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1889 mL | |
| 80 mM | 0.0357 mL | 0.1783 mL | 0.3567 mL | 0.8917 mL | |
| 100 mM | 0.0285 mL | 0.1427 mL | 0.2853 mL | 0.7134 mL |
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