Napsagatran
Napsagatran (Ro 46-6240) is a potent thrombin inhibitor. Napsagatran exhibits anticoagulant effects in vitro and in vivo. Napsagatran can be used in antithrombotic research[1][2].
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- No. CAS: 154397-77-0
- Fòrmula: C26H34N6O6S
- Peso molecular:558.65
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Napsagatran (10 μg/kg/min) reduces platelet-rich thrombus formation in an ex vivo perfusion chamber model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Napsagatran (10 μg/kg/min, i.v., infusion for 240 minutes) significantly reduces thrombus associated fibrin in rabbits[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand rabbits[2]
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Dosage:10 μg/kg/min
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Administration:i.v., infusion for 240 minutes
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Result:Showed a 1.3-fold prolongation of the prothrombin time (PT) and a 1.7-fold prolongation of the partial thromboplastin time (APTT).
Significantly reduced thrombus associated fibrin after 240 min blood flow exposure.
Showed no effects in heart rate, blood pressure, plasma fibrinogen concentrations, hematocrit and blood cell counts over time.
Chemical Information
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No. CAS 154397-77-0
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Peso molecular 558.65
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Fòrmula C26H34N6O6S
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SMILES
O=C(NC[C@H]1CN(C(N)=N)CCC1)C[C@@H](C(N(C2CC2)CC(O)=O)=O)NS(C3=CC4=CC=CC=C4C=C3)(=O)=O
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Synonyms
Ro 46-6240; Ro 46-6240/010
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Roux S, et al. Effects of napsagatran (Ro 46-6240), a new synthetic thrombin inhibitor and of heparin in a canine model of coronary artery thrombosis: comparison with an ex vivo annular perfusion chamber model. J Pharmacol Exp Ther. 1996 Apr;277(1):71-8. [Content Brief]
[2]. Himber J, et al. Inhibition of tissue factor limits the growth of venous thrombus in the rabbit. J Thromb Haemost. 2003 May;1(5):889-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Napsagatran Related Classifications
HY-15759 Related Classifications
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