Nec-4
Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
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- No. CAS: 1041644-43-2
- Fòrmula: C15H13ClFN3O
- Peso molecular:305.73
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
IC50: 2.6 μM (RIP1)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
0.092 μM
Compound: 48
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Inhibition of TNF-alpha-induced necroptosis in FADD-deficient human Jurkat T cells
Inhibition of TNF-alpha-induced necroptosis in FADD-deficient human Jurkat T cells
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[PMID: 18467094] |
Nec-4 (compound 9) is a slightly better competitor than 7 with a lower Ki value that is similar to R-3. Nec-4 is again a slightly better competitor than Rac-3 with Ki and IC50 values comparable to 7 (Nec-4: IC50=2.6±0.1 μM, Ki=0.46±0.05 μM; 7: IC50=10.7±1.8 μM, Ki=4.5±0.9 μM). Overall, all three compounds cross-compete with each other but Nec-4 is able to more effectively displace both 20 and 26 in comparison to the parent compounds Rac-3 and 7, respectively. This suggests that Nec-4 binding likely significantly overlaps with both the Nec-1 and the Nec-3 binding sites.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1041644-43-2
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Peso molecular 305.73
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Fòrmula C15H13ClFN3O
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SMILES
C[C@@H](C1=C(C=CC=C1Cl)F)NC(C2=CC=C(N2C)C#N)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nec-4 Related Classifications
HY-18900 Related Classifications
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