SGN-2FF
Based on 2 publication(s) in Google Scholar
SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.0%
- No. CAS: 2089647-47-0
- Fòrmula: C6H11FO4
- Peso molecular:166.15
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SGN-2FF
More
Actividad biológica
Descripciòn
IC50 & Target
Fucosyltransferase[1]
In Vitro
SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2089647-47-0
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Appearance Solid
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Peso molecular 166.15
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Fòrmula C6H11FO4
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Color White to off-white
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SMILES
F[C@H]1[C@@H]([C@@H]([C@H](C)OC1O)O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Hepatology
Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation. [Abstract]2025 Mar 1;81(3):774-790. PMID: 38985995 -
Microbiol Spectr
Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies. [Abstract]2025 Sep 2;13(9):e0086325. PMID: 40698943
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (300.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 36.67 mg/mL (220.70 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (300.93 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.0187 mL | 30.0933 mL | 60.1866 mL | 150.4665 mL |
| 5 mM | 1.2037 mL | 6.0187 mL | 12.0373 mL | 30.0933 mL | |
| 10 mM | 0.6019 mL | 3.0093 mL | 6.0187 mL | 15.0466 mL | |
| 15 mM | 0.4012 mL | 2.0062 mL | 4.0124 mL | 10.0311 mL | |
| 20 mM | 0.3009 mL | 1.5047 mL | 3.0093 mL | 7.5233 mL | |
| 25 mM | 0.2407 mL | 1.2037 mL | 2.4075 mL | 6.0187 mL | |
| 30 mM | 0.2006 mL | 1.0031 mL | 2.0062 mL | 5.0155 mL | |
| 40 mM | 0.1505 mL | 0.7523 mL | 1.5047 mL | 3.7617 mL | |
| 50 mM | 0.1204 mL | 0.6019 mL | 1.2037 mL | 3.0093 mL | |
| 60 mM | 0.1003 mL | 0.5016 mL | 1.0031 mL | 2.5078 mL | |
| 80 mM | 0.0752 mL | 0.3762 mL | 0.7523 mL | 1.8808 mL | |
| 100 mM | 0.0602 mL | 0.3009 mL | 0.6019 mL | 1.5047 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
SGN-2FF Related Classifications
HY-107366 Related Classifications
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