Triclosan
Based on 10 publication(s) in Google Scholar
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.98%
- No. CAS: 3380-34-5
- Fòrmula: C12H7Cl3O2
- Peso molecular:289.55
-
Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-13629
EtoposideTopoisomerase II Inhibitor -
HY-W018392
Mono-(2-ethylhexyl) phthalateEndogenous Metabolite -
HY-18739
Phorbol 12-myristate 13-acetatePKC Activator -
HY-A0067
OxybenzoneUltraviolet Light Filter -
HY-16911
AFN-1252FabI Inhibitor -
HY-B1805
TriclocarbanAntimicrobial -
HY-B1119R
Triclosan (Standard)Antibacterial Agent -
HY-B0133
NatamycinAntibiotic -
HY-B0133R
Natamycin (Standard)Antibiotic -
HY-B1358
Lincomycin hydrochloride monohydrateRibosome Inhibitor -
HY-B1350A
Fusidic acid sodium saltBacteriostatic Antibiotic
Publications Citing Use of MedChemExpress (MCE) Triclosan
More- Antioxidants (Basel). 2024 May 29;13(6):667. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Anal Chem. 2020 Mar 17;92(6):4419-4426. [Abstract]
- Environ Pollut. 2026 Apr 28:128223. [Abstract]
- Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]
- Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]
- ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]
- Viruses. 2019 Apr 25;11(4):385. [Abstract]
- SSRN. 2025 May 7.
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
Customer Validation & Images
-
Bio/Physico-chemical Assay
-
WB
-
IHC
-
Bio/Physico-chemical Assay
-
Bio/Physico-chemical Assay
Ver todos los productos específicos de isoformas Antibiotic
More
Actividad biológica
Descripciòn
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
20 μM
Compound: Triclosan
|
Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
|
[PMID: 19075064] |
| HepG2 | ED50 |
2 μg/mL
Compound: Triclosan
|
Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
|
[PMID: 23092194] |
| Vero | CC50 |
25 μM
Compound: TCS
|
Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation
Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation
|
[PMID: 33636304] |
In Vitro
Triclosan (1-100 μM ; 24 h) decreases in cell viability in dose and time dependent manners with 50 and 100 μM. Triclosan with 50 μM significantly increases cleaved caspase3 and Bax proteins and decreases Bcl-2[2].
Triclosan (50 μM ; 1-3 h) induces the increased expressions of both phosphorylated p38 and JNK proteins[2].
Triclosan (10-50 μM ; 3 h) with 50 μM decreases the GSH activity and increases the ROS generation to about 40% in cultured NSCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
-
Cell Line:Neural stem wells
-
Concentration:1, 10, 20, 30, 50 and 100 μM
-
Incubation Time:24 h
-
Result:Initiated the decreases in cell viability in dose and time dependent manners with 50 and 100 μM.
-
Cell Line:Neural stem wells
-
Concentration:50 μM
-
Incubation Time:1, 3 h
-
Result:Did not affect the expressions of MAPK signaling proteins per se.
Differentially induced the increased expressions of both phosphorylated p38 and JNK proteins.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wild type BALB/cJ mice[3]
-
Dosage:5, 50, 500 mg/kg
-
Administration:Oral gavage, five days a week for a total of four weeks
-
Result:Caused an increase in the production of anti-dermatophagoides farinae (Der f) IgE, IL-4, and IL-13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen-exposed wild type mice.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 3380-34-5
-
Appearance Solid
-
Peso molecular 289.55
-
Fòrmula C12H7Cl3O2
-
Color White to off-white
-
SMILES
OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (10)
-
Journal Impact Factor
-
Most Recent
-
Antioxidants (Basel)
Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. [Abstract]2024 May 29;13(6):667. PMID: 38929106 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Anal Chem
Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe. [Abstract]2020 Mar 17;92(6):4419-4426. PMID: 32053360 -
Environ Pollut
Triclosan exposure perturbs skin lipid metabolism and inflammatory pathways: Insights from network toxicology and multi-omics analyses. [Abstract]2026 Apr 28:128223. PMID: 42061800 -
Ecotoxicol Environ Saf
Triclosan exposure exacerbates muscle wasting via senescence and IGF-1 pathway suppression: A combined epidemiological and experimental study. [Abstract]2025 Oct 1:304:119142. PMID: 41045744
Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]
RCS regression analysis between ASMI and cr-corrected Triclosan. Beta (solid lines) and 95% confidence levels (shaded areas).
Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]
Protein levels of IGF-1, p-Akt, and p-mTOR were lower in the muscle of Triclosan (0-50 μM, 48 h)-exposed mice than the chow group.
Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]
IHC staining revealed a lower IGF-1 level in the Triclosan-exposed group than in the chow group.
-
Ecotoxicol Environ Saf
Microbial profiles and immune responses in seahorse gut and brood pouch under chronic exposure to environmental antibiotics. [Abstract]2023 Mar 15:253:114711. PMID: 36868035 -
ACS Omega
Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA. [Abstract]2020 Nov 15;5(46):29935-29942. PMID: 33251429
Triclosan purchased from MedChemExpress. Usage Cited in: ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]
Our data showed that triclosan can stabilize KasA with a △Tm of 3.8℃ using nanoDSF.
Triclosan purchased from MedChemExpress. Usage Cited in: ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]
Ratio of mean fluorescence 350/330 nm (1st derivative). KasA (10 μM) was tested in the presence of 100 μM of compounds. Sildenafil (purple) and triclosan (green) have a ΔTm of 6.7 and 3.8℃, respectively.
-
Viruses
Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus. [Abstract]2019 Apr 25;11(4):385. PMID: 31027241 -
-
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Solvente y solubilidad
In Vitro:
DMSO : ≥ 100 mg/mL (345.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Methanol : 100 mg/mL (345.36 mM; Need ultrasonic)
H2O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocolo
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
-
Apoptosis
Apoptosis, also called programmed cell death, is generally characterized by distinct morphological characteristics.
-
DSS-Induced Colitis
Dextran sulfate sodium (DSS)-induced colitis is generated by administering DSS in mouse drinking water, producing epithelial injury, barrier disruption, weight loss, diarrhea, fecal blood, colon shortening, histologic mucosal damage, and inflammatory mediator changes; the model is mainly used to study acute or chronic intestinal inflammation resembling selected features of ulcerative colitis. DSS injury is interpreted through clinical and tissue readouts rather than a single molecular endpoint: daily body weight, stool consistency, and bleeding are combined into a disease activity index, while colon length, histology, cytokines, myeloperoxidase activity, intestinal permeability, and tight-junction markers provide complementary measures of inflammation and barrier damage.
-
TNBS-Induced Colitis
TNBS-induced colitis is produced by intrarectal delivery of 2,4,6-trinitrobenzene sulfonic acid in ethanol, where ethanol disrupts the mucosal barrier and TNBS haptenates colonic proteins, generating immune-mediated colonic inflammation with weight loss, diarrhea, ulceration, transmural injury, inflammatory-cell infiltration, and cytokine responses. The model is used as an experimental intestinal inflammation model with Crohn’s disease–like features, especially when Th1-type responses, IL-12–dependent inflammation, chronic relapsing inflammation, or fibrosis-related endpoints are studied.
-
Apoptosis Solutions
Apoptosis is a regulated, generally non-lytic cell-death pathway that removes unwanted, damaged, infected, or abnormal cells through coordinated morphological changes, caspase activation, DNA fragmentation, and membrane remodeling. The intrinsic apoptosis pathway is controlled mainly by mitochondrial outer membrane permeabilization, BCL-2 family proteins, cytochrome c release, apoptosome formation, caspase-9 activation, and downstream executioner caspase-3/7 activation. The extrinsic apoptosis pathway is initiated by death receptors such as Fas, TNFR, and TRAIL receptors, which recruit adaptor proteins and activate caspase-8 before engaging executioner caspases or mitochondrial amplification through BID cleavage. Apoptosis is linked to many phenotypes, including cancer cell killing, tissue homeostasis, immune regulation, neurodegeneration, infection response, and treatment-induced cytotoxicity; unresolved questions include how apoptosis interacts with necroptosis, pyroptosis, ferroptos
Pureza y Documentación
-
Ficha de datos (278 KB)
-
SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4. [Content Brief]
[2]. Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul). 2016 Jan;24(1):99-107. [Content Brief]
[3]. Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13(1):136. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Methanol | 1 mM | 3.4536 mL | 17.2682 mL | 34.5364 mL | 86.3409 mL |
| 5 mM | 0.6907 mL | 3.4536 mL | 6.9073 mL | 17.2682 mL | |
| 10 mM | 0.3454 mL | 1.7268 mL | 3.4536 mL | 8.6341 mL | |
| 15 mM | 0.2302 mL | 1.1512 mL | 2.3024 mL | 5.7561 mL | |
| 20 mM | 0.1727 mL | 0.8634 mL | 1.7268 mL | 4.3170 mL | |
| 25 mM | 0.1381 mL | 0.6907 mL | 1.3815 mL | 3.4536 mL | |
| 30 mM | 0.1151 mL | 0.5756 mL | 1.1512 mL | 2.8780 mL | |
| 40 mM | 0.0863 mL | 0.4317 mL | 0.8634 mL | 2.1585 mL | |
| 50 mM | 0.0691 mL | 0.3454 mL | 0.6907 mL | 1.7268 mL | |
| 60 mM | 0.0576 mL | 0.2878 mL | 0.5756 mL | 1.4390 mL | |
| 80 mM | 0.0432 mL | 0.2159 mL | 0.4317 mL | 1.0793 mL | |
| 100 mM | 0.0345 mL | 0.1727 mL | 0.3454 mL | 0.8634 mL |
Triclosan Related Classifications
HY-B1119 Related Classifications
Powered by Bioz