Adintrevimab
Based on 2 publication(s) in Google Scholar
Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 96.94%
- No. CAS: 2516243-54-0
- Peso molecular:145.04 kDa
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Adintrevimab
More
Actividad biológica
Human IgG1 lambda2
Virus
Severe acute respiratory syndrome coronavirus 2
The crystallizable fragment (Fc) region of Adintrevimab has a modification to extend its half-life. Adintrevimab binds to a distinct epitope in the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 that partially overlaps the angiotensin-converting enzyme 2 binding site and is highly conserved among sarbecoviruses. In vitro, Adintrevimab has demonstrated potent neutralizing activity against most variants and sublineages of SARS-CoV-2 (including Alpha, Beta, Gamma, and Delta) as well as other SARS-like viruses. Adintrevimab displays reduced in vitro activity against Omicron BA.1/BA.1.1 and lacks activity against BA.2, BA.3, BA.4, and BA.5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Adintrevimab (5-25 mg/kg; i.v.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Syrian golden hamsters (5-6-week-old females; 75-125 g) infected with SARS-CoV-2/WA1/2020[1].
-
Dosage:9.25, 55, 333, or 2,000 μg (average range: 0.1 to 20 mg/kg)
-
Administration:Intraperitoneal injection; single dose
-
Result:Showed significant reduction in lung viral load and virus-induced lung pathology.
-
Animal Model:Rhesus macaques (5.6-8.8 years old; 6 females [4.4-6.3 kg] and 6 males [6.1-8.5 kg]) infected with SARS-CoV-2/WA1/2020[1].
-
Dosage:5 mg/kg, 25 mg/kg
-
Administration:Intravenous injection; single dose
-
Result:Reduced pulmonary inflammation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG1 lambda2
ELISA, FACS, Functional assay
Chemical Information
-
No. CAS 2516243-54-0
-
Appearance Liquid
-
Peso molecular 145.04 kDa
-
Color Colorless to light yellow
-
SMILES
[Adintrevimab]
-
Synonyms
ADG 20
-
Envío
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
JCI Insight
2023 Dec 22;8(24):e166540. PMID: 37676726 -
Pureza y Documentación
-
Ficha de datos (261 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Adintrevimab Related Classifications
HY-P99423 Related Classifications
Powered by Bioz