AF3485
AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.
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- No. CAS: 1195786-61-8
- Fòrmula: C22H17F3N2O2
- Peso molecular:398.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Actividad biológica
Chemical Information
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No. CAS 1195786-61-8
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Peso molecular 398.38
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Fòrmula C22H17F3N2O2
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SMILES
OCCN(C1=C2C=C(C=C1)NC(C3=CC=CC=C3C(F)(F)F)=O)C4=C2C=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AF3485 Related Classifications
HY-118184 Related Classifications
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