country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-N19313

Copy Link Print Information

Agelastatin D

Agelastatin D is a pyrrole-imidazole alkaloid and cytotoxic agent found in the Western Australian sponge Cymbastela sp.. Agelastatin D induces cytotoxic activity against cancer cells. Agelastatin D can be used for the research of chronic lymphocytic leukemia.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 201338-45-6
Fòrmula: C₁₁H₁₁BrN₄O₃
Peso molecular:327.13

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Agelastatin D Chemical Structure

No. CAS: 201338-45-6

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	13.7 μM Compound: 2b	Antitumor activity against human HeLa cells assessed as cell viability by MTT assay Antitumor activity against human HeLa cells assessed as cell viability by MTT assay	[PMID: 24673739]

In Vitro

Agelastatin D (compound 2b) exhibits cytotoxic activity against CLL1, CLL2, JVM-2, and HeLa cell lines with EC₅₀ values at 48 h of 91.1 μM, 29.0 μM, 13.2 μM, and 13.7 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

primary chronic lymphocytic leukemia (CLL) patient cell lines (CLL1, CLL2), immortalized leukemic JVM-2 cell line, HeLa cell line
Concentration:

dose-response format (CLL1, CLL2, JVM-2); dose-response format (HeLa)
Incubation Time:

48 h (CLL1, CLL2, JVM-2); overnight (HeLa)
Result:

Exhibited cytotoxic activity with EC₅₀ values of 91.1 μM (CLL1), 29.0 μM (CLL2), 13.2 μM (JVM-2), and 13.7 μM (HeLa).

Chemical Information

No. CAS 201338-45-6
Peso molecular 327.13
Fòrmula C₁₁H₁₁BrN₄O₃
SMILES

BrC(N1[C@@]2([H])[C@](N3)([H])[C@@]4([H])[C@@](C2)(NC(N4)=O)O)=CC=C1C3=O
Structure Classification
- Others
Initial Source
- Animals
Cymbastela sp.
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Stout EP, et al. Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies. J Med Chem. 2014;57(12):5085-5093. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto