AL-438
AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity.
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- No. CAS: 239066-73-0
- Fòrmula: C23H25NO2
- Peso molecular:347.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Ki: 2.5 nM (glucocorticoid receptor)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CV-1 | EC50 |
33 nM
Compound: 18
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Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor
Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor
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[PMID: 12620078] |
| HepG2 | EC50 |
13 nM
Compound: 18
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Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor
Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor
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[PMID: 12620078] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats (carrageenan paw edema model)[2]
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Dosage:1, 10, 100 mg/kg
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Administration:P.o.
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Result:Showed antiinflammatory activity with ED50 value of 11 mg/kg in acute inflammation assay.
Chemical Information
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No. CAS 239066-73-0
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Peso molecular 347.45
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Fòrmula C23H25NO2
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SMILES
C=CCC1OC2=CC=CC(OC)=C2C3=C1C4=C(NC(C)(C)C=C4C)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. [Content Brief]
[2]. Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AL-438 Related Classifications
HY-114154 Related Classifications
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