ALG-001075
Based on 1 Customer Validation
ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.83%
- No. CAS: 2495324-66-6
- Fòrmula: C22H19FN4O4
- Peso molecular:422.41
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Orally Active Compound Library
HY-L061
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
Clinical Compound Library Plus
HY-L026P
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Alkyne Compound Library
HY-L258
-
Anti-Infection Compound Library
HY-L002
-
Clinical Compound Library
HY-L026
-
Antiviral Compound Library
HY-L027
-
Drug Repurposing Compound Library
HY-L035
Actividad biológica
ALG-001075 (Compound 10) (0.01-1000 nM) inhibits HBV DNA production in HepG2.117cells with an EC50 of 0.63 nM and an EC90 of 3.17 nM[1]. ALG-001075 (0.01-1000 nM) effectively blocks not only HBV DNA production (EC50 = 1.98 nM) but also extracellular HBsAg (EC50 = 70 nM), HBeAg (EC50 = 10.5 nM) and intracellular HBV RNA (EC50 = 54.7 nM) in primary human hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | CL | Vss | T1/2 | AUCinf | Tmax | Cmax | F |
|---|---|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[1] | 1 mg/kg | i.v. | 7.89 mL/min/kg | 0.89 L/kg | 1.85 h | 2235 ng·h/mL | / | / | / |
| Cynomolgus Monkey[1] | 5 mg/kg | p.o. | / | / | 14.4 h | 2189 ng·h/mL | 1.17 h | 490 ng/mL | 19.6 % |
| Dog[1] | 1 mg/kg | i.v. | 1.97 mL/min/kg | 1.03 L/kg | 6.38 h | 8519 ng·h/mL | / | / | / |
| Dog[1] | 5 mg/kg | p.o. | / | / | 7.83 h | 24494 ng·h/mL | 2.17 h | 1903 ng/mL | 57.5 % |
| Mice[1] | 1 mg/kg | i.v. | 12.0 mL/min/kg | 1.00 L/kg | 1.37 h | 1394 ng·h/mL | / | / | / |
| Mice[1] | 5 mg/kg | p.o. | / | / | 1.55 h | 7987 ng·h/mL | 1.00 h | 2287 ng/mL | 115 % |
| Rat[1] | 1 mg/kg | i.v. | 6.09 mL/min/kg | 0.50 L/kg | 1.64 h | 2778 ng·h/mL | / | / | / |
| Rat[1] | 5 mg/kg | p.o. | / | / | 2.17 h | 8723 ng·h/mL | 1.67 h | 1833 ng/mL | 62.8 % |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male 5-6 weeks old C57BL/6 mice adeno-associated virus (AAV) HBV[1]
-
Dosage:15, 50 mg/kg
-
Administration:p.o. twice daily for 56 days
-
Result:Showed pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 2495324-66-6
-
Appearance Solid
-
Peso molecular 422.41
-
Fòrmula C22H19FN4O4
-
SMILES
N#CC1=CC(NC(C2=C(C)C(C(C(NC3(COC3)C#C)=O)=O)=C(C)N2C)=O)=CC=C1F
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 70 mg/mL (165.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (274 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3674 mL | 11.8368 mL | 23.6737 mL | 59.1842 mL |
| 5 mM | 0.4735 mL | 2.3674 mL | 4.7347 mL | 11.8368 mL | |
| 10 mM | 0.2367 mL | 1.1837 mL | 2.3674 mL | 5.9184 mL | |
| 15 mM | 0.1578 mL | 0.7891 mL | 1.5782 mL | 3.9456 mL | |
| 20 mM | 0.1184 mL | 0.5918 mL | 1.1837 mL | 2.9592 mL | |
| 25 mM | 0.0947 mL | 0.4735 mL | 0.9469 mL | 2.3674 mL | |
| 30 mM | 0.0789 mL | 0.3946 mL | 0.7891 mL | 1.9728 mL | |
| 40 mM | 0.0592 mL | 0.2959 mL | 0.5918 mL | 1.4796 mL | |
| 50 mM | 0.0473 mL | 0.2367 mL | 0.4735 mL | 1.1837 mL | |
| 60 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9864 mL | |
| 80 mM | 0.0296 mL | 0.1480 mL | 0.2959 mL | 0.7398 mL | |
| 100 mM | 0.0237 mL | 0.1184 mL | 0.2367 mL | 0.5918 mL |
ALG-001075 Related Classifications
HY-177022 Related Classifications
Powered by Bioz