Anticancer agent 32
Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer.
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- No. CAS: 2222930-76-7
- Fòrmula: C24H21F2N5O
- Peso molecular:433.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
IC50: 17.2 μM (MGC-803), 12.3 μM (HeLa), 40.6 μM (NCI-H460), 46.8 μM (HepG2), 95.4 μM (SMMC-7721), 8.9 μM (T-24), 86.8 μM (HL-7702)[1]
Anticancer agent 32 (2.5-40 μM; 48 h) shows cytotoxic activities to cancer cell lines[1]. Anticancer agent 32 (0-16 μM; 24 h) affects cell cycle, induces cell apoptosis, increases intracellular levels of Ca2+ and ROS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cell lines
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Concentration:2.5, 5, 10, 20 and 40 μM
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Incubation Time:48 hours
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Result:Inhibited cell growth with IC50 values of 17.2, 12.3, 40.6, 46.8, 95.4, 8.9 and 86.8 μM for MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cells, respectively.
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Cell Line:MGC-803 and T-24 cell lines
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Concentration:0, 8 and 12 μM
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Incubation Time:24 hours
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Result:Significantly induced cell cycle arrest at the G2/M phase in T-24 cells.
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Cell Line:MGC-803 and T-24 cell lines
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Concentration:4, 8 and 12 μM
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Incubation Time:24 hours
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Result:Decreased expression level of cyclin B1.
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Cell Line:MGC-803 and T-24 cell lines
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Concentration:0, 4, 8 and 16 μM
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Incubation Time:24 hours
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Result:Induced cell apoptosis of T-24 cells from 8.21 to 32.91% after treatment by increasing levels of caspase-3 and caspase-9 in T-24 cells.
Chemical Information
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No. CAS 2222930-76-7
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Peso molecular 433.45
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Fòrmula C24H21F2N5O
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SMILES
CC1=CC(C)=CC(NC(NC2=CC=CC(CNC3=NC4=CC(F)=C(C=C4N=C3)F)=C2)=O)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 32 Related Classifications
HY-143303 Related Classifications
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