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Referencia número: HY-151957

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Antitubercular agent 34

Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of Mtb_H37Rv with a MIC₉₀ value of 1.25 μg/mL with the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent 34 can be used for the research of tuberculosis.

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No. CAS: 2883173-23-5
Fòrmula: C₁₉H₁₄N₄O₂S
Peso molecular:362.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antitubercular agent 34 Chemical Structure

No. CAS: 2883173-23-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
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Referencias
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	IC₅₀	11.9 μg/mL Compound: 42g	Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 36399878]

In Vitro

Antitubercular agent 34 (0-20 μg/mL; 3-4 d) shows inhibitory effect to Mtb_H37Rv with a MIC₉₀ value of 1.25 μg/mL^[1].
Antitubercular agent 34 (0-100 μM; 3 d) shows inhibitory effect to human monocytes THP-I cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human monocytes THP-I cell line
Concentration:

1, 10, 50 and 100 μM
Incubation Time:

72 hours
Result:

Inhibited the growth of THP-I cells with an IC₅₀ value of 11.9 μg/mL.

Chemical Information

No. CAS 2883173-23-5
Peso molecular 362.41
Fòrmula C₁₉H₁₄N₄O₂S
SMILES

O=C(C1=NOC(C2=CSC(NC3=CC=CC=C3)=N2)=C1)NC4=CC=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Girardini M, et al. Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit-to-lead optimization and release of a novel antitubercular chemotype via scaffold derivatization. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114916. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Antitubercular agent 34

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Antitubercular agent 34

Actividad biológica

Descripciòn

Cellular Effect

In Vitro

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Antitubercular agent 34 Related Classifications

HY-151957 Related Classifications

Bioz

Keywords

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