AS3580239
AS3580239 is a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR). AS3580239 promotes acetylcholine (ACh) signaling via m-nAChR, causing a leftward shift of the ACh concentration-response curve. AS3580239 enhances electrically stimulated isometric contraction of the extensor digitorum longus (EDL) muscle. AS3580239 improves neurotransmission and enhances muscle strength. AS3580239 can be used for research on myasthenia gravis.
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- Fòrmula: C27H22F3N5O7S2
- Peso molecular:649.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
AS3580239 (1-10 μM) acts as a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptors in differentiated Hu5/KD3 human myotubes, reducing the EC50 of ACh by 14.0-fold at 10 μM without inducing currents on its own, and its effects are blocked by the acetylcholine receptor antagonist tubocurarine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 649.62
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Fòrmula C27H22F3N5O7S2
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SMILES
FC(F)(F)C(N=C(NC(C(N1C)=C(O)C2=C(C=C(OCC(CO)O)C=C2)S1(=O)=O)=O)S3)=C3C(C=N4)=CN=C4C5=CC=CC=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS3580239 Related Classifications
HY-188047 Related Classifications
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