ATC0175
Based on 1 publication(s) in Google Scholar
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.70%
- No. CAS: 510733-97-8
- Fòrmula: C23H26ClF2N5O
- Peso molecular:461.94
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) ATC0175
More
Actividad biológica
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5-HT1A Receptor |
5-HT2B Receptor |
ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 510733-97-8
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Appearance Solid
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Peso molecular 461.94
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Fòrmula C23H26ClF2N5O
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Color White to light yellow
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SMILES
CN(C1=NC(N[C@H](CC2)CC[C@H]2NC(C(C=C3)=CC(F)=C3F)=O)=NC4=C1C=CC=C4)C.Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur Arch Psychiatry Clin Neurosci
Genetic factors and symptom dimensions associated with antidepressant treatment outcomes: clues for new potential therapeutic targets?. [Abstract]2024 Aug 27. PMID: 39191930
Solvente y solubilidad
DMSO : 12.5 mg/mL (27.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1648 mL | 10.8239 mL | 21.6478 mL | 54.1196 mL |
| 5 mM | 0.4330 mL | 2.1648 mL | 4.3296 mL | 10.8239 mL | |
| 10 mM | 0.2165 mL | 1.0824 mL | 2.1648 mL | 5.4120 mL | |
| 15 mM | 0.1443 mL | 0.7216 mL | 1.4432 mL | 3.6080 mL | |
| 20 mM | 0.1082 mL | 0.5412 mL | 1.0824 mL | 2.7060 mL | |
| 25 mM | 0.0866 mL | 0.4330 mL | 0.8659 mL | 2.1648 mL |
ATC0175 Related Classifications
HY-107624 Related Classifications
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