BAY-u 9773
Based on 1 publication(s) in Google Scholar
BAY-u 9773 is a selective cysteinyl-leukotriene receptor antagonist. BAY-u 9773 competitively antagonizes cysteinyl-leukotriene-induced contractions at typical and atypical cysteinyl-leukotriene receptors with comparable activity. BAY-u 9773 can be used for the research of trichomoniasis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 154978-38-8
- Fòrmula: C27H36O5S
- Peso molecular:472.64
-
Almacenamiento:
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-19989
MK-571ABCC1/MRP4 Inhibitor -
HY-107608
Leukotriene B4PROTAC linker -
HY-17492
ZafirlukastLeukotriene Receptor Antagonist -
HY-19989A
MK-571 sodiumABCC1/MRP4 Inhibitor -
HY-15744
LY255283LTB4 Receptor Antagonist -
HY-107610
SR2640 hydrochlorideLTD4/LTE4 Antagonist -
HY-113465
Leukotriene E4Cysteinyl Leukotriene Pathway Marker -
HY-17492R
Zafirlukast (Standard)Leukotriene Receptor Antagonist -
HY-112248A
HAMI 3379CysLT2 Receptor Antagonist -
HY-111212
TomelukastLeukotriene D4/E4 Antagonist -
HY-107607
FPL-55712 free baseleukotriene Receptor Antagonist -
HY-76511
VerlukastLeukotriene Receptor Antagonist
Publications Citing Use of MedChemExpress (MCE) BAY-u 9773
MoreVer todos los productos específicos de isoformas Leukotriene Receptor
More
Actividad biológica
Descripciòn
IC50 & Target
[1]|
CysLT1 |
CysLT2 |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.44 μM
Compound: BAY-u9773
|
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
|
[PMID: 25408836] |
| HEK293 | IC50 |
0.3 μM
Compound: BAY-u9773
|
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
|
[PMID: 25408836] |
In Vitro
BAY u9773 (10 nM-10 μM; 15 min) competitively displaces [3H] leukotriene D4 binding to guinea-pig lung membranes with a mean pKi of 7.0[1].
BAY-u 9773 (1-10 μM; 30 min pretreatment) dose-dependently inhibits TvSP- and LTC4-induced MCP-1 secretion in HMC-1 cells, with the strongest effect observed at 10 μM[2].
BAY-u 9773 (1-5 μM) dose-dependently inhibits TvSP- and LTC4-induced ROS production in HMC-1 cells, with significant suppression at concentrations ≥1 μM[2].
BAY-u 9773 (5 μM) inhibits TvSP- and LTC4-induced migration of HMC-1 cells by approximately 60%[2].
BAY-u 9773 (1-5 μM) dose-dependently inhibits TvSP- and LTC4-induced degranulation (measured via CD63 expression) in HMC-1 cells, with the strongest effect at 5 μM[2].
BAY-u 9773 inhibits TvSP-induced p47phox phosphorylation in HMC-1 cells[2].
BAY-u 9773 inhibits TvSP- and LTC4-induced NF-κB phosphorylation in HMC-1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
-
Cell Line:HMC-1
-
Concentration:1 μM; 3 μM; 10 μM
-
Incubation Time:30 min pretreatment
-
Result:Dose-dependently inhibited TvSP-induced MCP-1 secretion, reducing levels to ~260 pg/mL at 10 μM compared to ~460 pg/mL in untreated TvSP-stimulated cells.
Dose-dependently inhibited LTC4-induced MCP-1 secretion, reducing levels to ~270 pg/mL at 10 μM compared to ~460 pg/mL in untreated LTC4-stimulated cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 154978-38-8
-
Appearance Liquid
-
Peso molecular 472.64
-
Fòrmula C27H36O5S
-
Color Colorless to light yellow
-
SMILES
OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCCC)SC1=CC=C(C=C1)C(O)=O)=O
-
Envío
Shipping with dry ice.
-
Almacenamiento
-80°C, protect from light
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Biol Chem
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway. [Abstract]2024 Aug;300(8):107530. PMID: 38971310
Pureza y Documentación
-
Ficha de datos (269 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Tudhope SR, et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. Eur J Pharmacol. 1994;264(3):317-323. [Content Brief]
[2]. Lee YA, et al. Trichomonas vaginalis-secreted cysteinyl leukotrienes promote migration, degranulation and MCP-1 production in mast cells. Parasite Immunol. 2020;42(12):e12789. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAY-u 9773 Related Classifications
HY-107609 Related Classifications
Powered by Bioz