BC-23
Based on 1 Customer Validation
BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 97.37%
- No. CAS: 6298-15-3
- Fòrmula: C21H14ClN3O4S
- Peso molecular:439.87
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Ubiquitination Compound Library
HY-L050
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Anti-Blood Cancer Compound Library
HY-L079
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Protease Inhibitor Library
HY-L147
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Highly Selective Inhibitors Library
HY-L158
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12.19 μM
Compound: PI-083
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Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
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[PMID: 22437113] |
| DU-145 | IC50 |
10.82 μM
Compound: PI-083
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Antiproliferative activity against human DU145 cells
Antiproliferative activity against human DU145 cells
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[PMID: 22437113] |
| KB | IC50 |
9.57 μM
Compound: PI-083
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Antiproliferative activity against human KB cells
Antiproliferative activity against human KB cells
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[PMID: 22437113] |
| MCF7 | IC50 |
1.96 μM
Compound: PI-083
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Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs MTT assay
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[PMID: 33039723] |
| MCF7 | IC50 |
6 μM
Compound: PI-083, NSC-45382
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Inhibition of 26S proteasome-mediated chymotrypsin like proteolytic activity in human MCF7 cells
Inhibition of 26S proteasome-mediated chymotrypsin like proteolytic activity in human MCF7 cells
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[PMID: 20621484] |
Chemical Information
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No. CAS 6298-15-3
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Appearance Solid
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Peso molecular 439.87
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Fòrmula C21H14ClN3O4S
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Color Orange to red
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SMILES
O=S(C1=CC=C(C=C1)NC(C2=O)=C(C(C3=C2C=CC=C3)=O)Cl)(NC4=NC=CC=C4)=O
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Synonyms
NSC 45382
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 25 mg/mL (56.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. [Content Brief]
[2]. Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2734 mL | 11.3670 mL | 22.7340 mL | 56.8350 mL |
| 5 mM | 0.4547 mL | 2.2734 mL | 4.5468 mL | 11.3670 mL | |
| 10 mM | 0.2273 mL | 1.1367 mL | 2.2734 mL | 5.6835 mL | |
| 15 mM | 0.1516 mL | 0.7578 mL | 1.5156 mL | 3.7890 mL | |
| 20 mM | 0.1137 mL | 0.5683 mL | 1.1367 mL | 2.8417 mL | |
| 25 mM | 0.0909 mL | 0.4547 mL | 0.9094 mL | 2.2734 mL | |
| 30 mM | 0.0758 mL | 0.3789 mL | 0.7578 mL | 1.8945 mL | |
| 40 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4209 mL | |
| 50 mM | 0.0455 mL | 0.2273 mL | 0.4547 mL | 1.1367 mL |
BC-23 Related Classifications
HY-119288 Related Classifications
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